GSK 2033

Catalog # Availability Size / Price Qty
5694/10
5694/50
Cat.No. 5694 - GSK 2033 | C29H28F3NO5S | CAS No. 1221277-90-2
1 Image
Description: Potent LXR antagonist

Chemical Name: 2,4,6-Trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]benzenesulfonamide

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

Potent LXR antagonist (pIC50 = 7.5). Enhances T-cell proliferation and blocks T 0901317-antiproliferative activity on T-cells. Cell permeable.

Technical Data

M.Wt:
591.66
Formula:
C29H28F3NO5S
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1221277-90-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. LXR-mediated inhibition of CD4+ T helper cells.
    Solt L, Kamenecka T, Burris T
    PLoS ONE, 2012;7(9):e46615.
  2. Discovery of tertiary sulfonamides as potent liver X receptor antagonists.
    Zuercher et al.
    J.Med.Chem., 2010;53:3412

Product Datasheets

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Citation for GSK 2033

The citations listed below are publications that use Tocris products. Selected citations for GSK 2033 include:

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