Chemical Name: 2,4,6-Trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]benzenesulfonamide
Biological ActivityPotent LXR antagonist (pIC50 = 7.5). Enhances T-cell proliferation and blocks T 0901317-antiproliferative activity on T-cells. Cell permeable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
LXR-mediated inhibition of CD4+ T helper cells.
Solt L, Kamenecka T, Burris T
PLoS ONE, 2012;7(9):e46615.
Discovery of tertiary sulfonamides as potent liver X receptor antagonists.
Zuercher et al.
Citations for GSK 2033
The citations listed below are publications that use Tocris products. Selected citations for GSK 2033 include:
3 Citations: Showing 1 - 3
PNPLA3 I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells.
Authors: Bruschi Et al.
Hepatol Commun 2019;3:1191
Phytosterols Inhibit Side-Chain Oxysterol Mediated Activation of LXR in Breast Cancer Cells.
Authors: Hutchinson Et al.
Int J Mol Sci 2019;20
Differential Effects of Retinoic Acid Concentrations in Regulating Blood-Brain Barrier Properties.
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