Catalog Number: 5694
Chemical Name: 2,4,6-Trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]benzenesulfonamide
Biological Activity
Potent LXR antagonist (pIC50 = 7.5). Enhances T-cell proliferation and blocks T 0901317-antiproliferative activity on T-cells. Cell permeable.
Technical Data
  • M.Wt:
    591.66
  • Formula:
    C29H28F3NO5S
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    1221277-90-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. LXR-mediated inhibition of CD4+ T helper cells.
    Solt L, Kamenecka T, Burris T
    PLoS ONE, 2012;7(9):e46615.
  2. Discovery of tertiary sulfonamides as potent liver X receptor antagonists.
    Zuercher et al.
    J.Med.Chem., 2010;53:3412

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