Chemical Name: 2,4,6-Trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]benzenesulfonamide
Biological ActivityPotent LXR antagonist (pIC50 = 7.5). Enhances T-cell proliferation and blocks T 0901317-antiproliferative activity on T-cells. Cell permeable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
LXR-mediated inhibition of CD4+ T helper cells.
Solt L, Kamenecka T, Burris T
PLoS ONE, 2012;7(9):e46615.
Discovery of tertiary sulfonamides as potent liver X receptor antagonists.
Zuercher et al.
Citation for GSK 2033
The citations listed below are publications that use Tocris products. Selected citations for GSK 2033 include:
1 Citation: Showing 1 - 1
Differential Effects of Retinoic Acid Concentrations in Regulating Blood-Brain Barrier Properties.
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