Catalog Number: 2373
Chemical Name: N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzenesulfonamide
Biological Activity
Potent, high affinity liver X receptor (LXR) agonist (EC50 ~ 50 nM, Kd values are 7 and 22 nM for LXR-α and LXR-β respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid-β production in primary neurons in vitro. Displays an EC50 of ~ 5 μM for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid. Also exhibits inverse agonist activity at constitutive androstane receptors (CAR).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers.
    Repa et al.
    Science, 2000;289:1524
  2. T0901317, a potent LXR agonist, is an inverse agonist of CAR.
    Kanno et al.
    J.Toxicol.Sci., 2013;38:309
  3. The liver X receptor ligand T0901317 decreases amyloid β production in vitro and in a mouse model of Alzheimer's disease.
    Koldamova et al.
    J.Biol.Chem., 2005;280:4079
  4. T0901317 is a dual LXR/FXR agonist.
    Houck et al.
    Mol.Gen.Metab., 2004;83:184

The citations listed below are publications that use Tocris products. Selected citations for T 0901317 include:

Showing Results 1 - 2 of 2

  1. Antiproliferative effects and mechanisms of liver X receptor ligands in pancreatic ductal adenocarcinoma cells.
    Authors: Candelaria Et al.
    J Biomol Screen
  2. Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture.
    Authors: Wahlang Et al.
    Toxicol Sci
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information

Molarity Calculator
Calculate the mass, volume or concentration required for a solution

The molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol)
An example of a molarity calculation using the molarity calculator:
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?

R&D Systems Guarantee

or select another batch:


Customer Information