Catalog Number: 2373
Chemical Name: N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzenesulfonamide
Biological Activity
Potent, high affinity liver X receptor (LXR) agonist (EC50 ~ 50 nM, Kd values are 7 and 22 nM for LXR-α and LXR-β respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid-β production in primary neurons in vitro. Displays an EC50 of ~ 5 μM for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid. Also exhibits inverse agonist activity at constitutive androstane receptors (CAR).
Technical Data
  • M.Wt:
    481.33
  • Formula:
    C17H12F9NO3S
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    293754-55-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers.
    Repa et al.
    Science, 2000;289:1524
  2. T0901317, a potent LXR agonist, is an inverse agonist of CAR.
    Kanno et al.
    J.Toxicol.Sci., 2013;38:309
  3. The liver X receptor ligand T0901317 decreases amyloid β production in vitro and in a mouse model of Alzheimer's disease.
    Koldamova et al.
    J.Biol.Chem., 2005;280:4079
  4. T0901317 is a dual LXR/FXR agonist.
    Houck et al.
    Mol.Gen.Metab., 2004;83:184
Citations:

The citations listed below are publications that use Tocris products. Selected citations for T 0901317 include:

6 Citations: Showing 1 - 6
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  1. Liver X receptor activation promotes differentiation of regulatory T cells.
    Authors: Herold
    PLoS One 2017;12(9):e0184985
  2. Liver X receptors activation, through TO901317 binding, reduces neuroinflammation in Parkinson's disease.
    Authors: Paterniti
    PLoS One 2017;12(4):e0174470
  3. The transcription cofactor CRTC1 protects from aberrant hepatic lipid accumulation
    Authors: Kim Et al.
    Scientific Reports 2016;6:37280
  4. The fatty acid synthase inhibitor platensimycin improves insulin resistance without inducing liver steatosisin mice and monkeys
    Authors: Singh Et al.
    PLoS One 2016;11:e0164133
  5. Antiproliferative effects and mechanisms of liver X receptor ligands in pancreatic ductal adenocarcinoma cells.
    Authors: Candelaria Et al.
    J Biomol Screen 2014;9:e106289
  6. Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture.
    Authors: Wahlang Et al.
    Toxicol Sci 2014;140:283

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