T 0901317

  ( 6 citations )    
Product Datasheet
Catalog Number:2373
Chemical Name:N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzenesulfonamide
Product Details
Citations (6)
Reviews
Biological Activity
Potent, high affinity liver X receptor (LXR) agonist (EC50 ~ 50 nM, Kd values are 7 and 22 nM for LXR-α and LXR-β respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid-β production in primary neurons in vitro. Displays an EC50 of ~ 5 μM for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid. Also exhibits inverse agonist activity at constitutive androstane receptors (CAR).
Technical Data
  • M.Wt:
    481.33
  • Formula:
    C17H12F9NO3S
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    293754-55-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for T 0901317 include:

6 Citations: Showing 1 - 6
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  1. Liver X receptor activation promotes differentiation of regulatory T cells.
    Authors: Herold
    PLoS One  2017;12(9):e0184985
  2. Liver X receptors activation, through TO901317 binding, reduces neuroinflammation in Parkinson's disease.
    Authors: Paterniti
    PLoS One  2017;12(4):e0174470
  3. The transcription cofactor CRTC1 protects from aberrant hepatic lipid accumulation
    Authors: Kim Et al.
    Scientific Reports  2016;6:37280
  4. The fatty acid synthase inhibitor platensimycin improves insulin resistance without inducing liver steatosisin mice and monkeys
    Authors: Singh Et al.
    PLoS One  2016;11:e0164133
  5. Antiproliferative effects and mechanisms of liver X receptor ligands in pancreatic ductal adenocarcinoma cells.
    Authors: Candelaria Et al.
    J Biomol Screen  2014;9:e106289
  6. Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture.
    Authors: Wahlang Et al.
    Toxicol Sci  2014;140:283

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