T 0901317

Catalog # Availability Size / Price Qty
2373/10
2373/50
T 0901317 | CAS No. 293754-55-9 | LXR-like Receptor Agonists
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Description: Potent liver X receptor (LXR) agonist; also CAR inverse agonist

Chemical Name: N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzenesulfonamide

Purity: ≥98%

Product Details
Citations (8)
Reviews

Biological Activity

Potent, high affinity liver X receptor (LXR) agonist (EC50 ~ 50 nM, Kd values are 7 and 22 nM for LXR-α and LXR-β respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid-β production in primary neurons in vitro. Displays an EC50 of ~ 5 μM for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid. Also exhibits inverse agonist activity at constitutive androstane receptors (CAR).

Technical Data

M.Wt:
481.33
Formula:
C17H12F9NO3S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
293754-55-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. T0901317, a potent LXR agonist, is an inverse agonist of CAR.
    Kanno et al.
    J.Toxicol.Sci., 2013;38:309
  2. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers.
    Repa et al.
    Science, 2000;289:1524
  3. The liver X receptor ligand T0901317 decreases amyloid β production in vitro and in a mouse model of Alzheimer's disease.
    Koldamova et al.
    J.Biol.Chem., 2005;280:4079
  4. T0901317 is a dual LXR/FXR agonist.
    Houck et al.
    Mol.Gen.Metab., 2004;83:184
  5. The nuclear receptor LXR is a glucose sensor.
    Mitro et al.
    Nature Lett., 2007;445:219

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Citations for T 0901317

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