Potent, high affinity liver X receptor (LXR) agonist (EC50
~ 50 nM, Kd
values are 7 and 22 nM for LXR-α
respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid-β
production in primary neurons in vitro
. Displays an EC50
of ~ 5 μ
M for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid. Also exhibits inverse agonist activity at constitutive androstane receptors (CAR).
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All Tocris products are intended for laboratory research use only.
Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers.
Repa et al.
T0901317, a potent LXR agonist, is an inverse agonist of CAR.
Kanno et al.
The liver X receptor ligand T0901317 decreases amyloid β production in vitro and in a mouse model of Alzheimer's disease.
Koldamova et al.
T0901317 is a dual LXR/FXR agonist.
Houck et al.
The citations listed below are publications that use Tocris products. Selected citations for T 0901317 include:
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