GSK 2194069

Catalog # Availability Size / Price Qty
5303/5
5303/25
GSK 2194069 | CAS No. 1332331-08-4 | Fatty Acid Synthase Inhibitors
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Description: Potent human fatty acid synthase (hFASN) inhibitor

Chemical Name: 4-[4-(5-Benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Purity: ≥99%

Product Details
Citations (2)
Reviews

Biological Activity

GSK 2194069 is a potent human fatty acid synthase (hFASN) inhibitor (IC50 = 7.7 nM); inhibits hFAS β-ketoacyl reductase activity. Inhibits lipid synthesis and attenuates proliferation of A549 non-small-cell lung cancer cells (EC50 = 15 nM) in vitro. GSK 2194069 also inhibits infection by SARS-CoV-2 (EC50 = 0.9 nM) in vitro.

Technical Data

M.Wt:
428.48
Formula:
C25H24N4O3
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1332331-08-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline

Background References

  1. A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site.
    Hardwicke et al.
    Nat.Chem.Biol., 2014;10:774

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Citations for GSK 2194069

The citations listed below are publications that use Tocris products. Selected citations for GSK 2194069 include:

2 Citations: Showing 1 - 2

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