Chemical Name: 4-[4-(5-Benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one
Biological ActivityGSK 2194069 is a potent human fatty acid synthase (hFASN) inhibitor (IC50 = 7.7 nM); inhibits hFAS β-ketoacyl reductase activity. Inhibits lipid synthesis and attenuates proliferation of A549 non-small-cell lung cancer cells (EC50 = 15 nM) in vitro. GSK 2194069 also inhibits infection by SARS-CoV-2 (EC50 = 0.9 nM) in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site.
Hardwicke et al.
Citations for GSK 2194069
The citations listed below are publications that use Tocris products. Selected citations for GSK 2194069 include:
2 Citations: Showing 1 - 2
Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication.
Authors: Chu Et al.
SREBP1-dependent de novo fatty acid synthesis gene expression is elevated in malignant melanoma and represents a cellular survival trait.
Authors: Wu and Näär
Sci Rep 2019;9:10369
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