GSK 2334470

Key Product Details

Product Description

GSK 2334470 is a potent 3-phosphoinositide-dependent protein kinase (PDPK1) inhibitor (IC₅₀ ~ 10 nM). Exhibits no effect on other kinases including Aurora, ROCK, p38 MAPK and PI 3-K. Suppresses T-loop phosphorylation and subsequent activation of PDK1 substrates S6K1, SGK and RSK in vitro; exhibits limited inhibitory effect on Akt activation. Delays melanomagenesis and metastasis in Braf^V600E::Pten^(-/-) mice.

Licensing Information

Sold for research purposes only under agreement from GlaxoSmithKline

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of GSK 2334470 is reviewed on the chemical probes website.

Product Specifications for GSK 2334470

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GSK 2334470

The following data is based on the product molecular weight 462.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.16 mL	10.81 mL	21.62 mL
5 mM	0.43 mL	2.16 mL	4.32 mL
10 mM	0.22 mL	1.08 mL	2.16 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 29 publications citing the usage of this product.

• Scortegagna Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf^V600E::Pten^(-/-) melanoma. Oncogene 2014 PMID: 24037523
• Najafov Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. Biochem.J. 2011 PMID: 21087210

Product Documents for GSK 2334470