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GSK 2334470

4143 5 Citations Datasheet / COA / SDS
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4143/10
4143/50
GSK 2334470 | CAS No. 1227911-45-6 | PDK-1 Inhibitors
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Description: Highly potent, selective PDPK1 (PDK1) inhibitor

Chemical Name: (3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide

Purity: ≥98%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Potent 3-phosphoinositide-dependent protein kinase (PDPK1) inhibitor (IC50 ~ 10 nM). Exhibits no effect on other kinases including Aurora, ROCK, p38 MAPK and PI 3-K. Suppresses T-loop phosphorylation and subsequent activation of PDK1 substrates S6K1, SGK and RSK in vitro; exhibits limited inhibitory effect on Akt activation. Delays melanomagenesis and metastasis in BrafV600E::Pten(-/-) mice.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of GSK 2334470 is reviewed on the chemical probes website.

Technical Data

M.Wt:
462.59
Formula:
C25H34N8O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1227911-45-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes only under agreement from GlaxoSmithKline

Product Datasheets

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Citations for GSK 2334470

The citations listed below are publications that use Tocris products. Selected citations for GSK 2334470 include:

5 Citations: Showing 1 - 5

  1. The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner.
    Authors: Heberle Et al.
    Life Sci Alliance  2019;2
  2. The 3-Phosphoinositide-Dependent Protein Kinase 1 Inhibits Rod Photoreceptor Development.
    Authors: Xing Et al.
    Front Cell Dev Biol  2018;6:134
  3. Retinoic acid regulates Kit translation during spermatogonial differentiation in the mouse.
    Authors: Busada Et al.
    Oncotarget  2015;397:140
  4. PDK1-mTOR signaling pathway inhibitors reduce cell proliferation in MK2206 resistant neuroblastoma cells.
    Authors: Qi Et al.
    Cancer Cell Int  2015;15:91
  5. Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer.
    Authors: Al-Ejeh Et al.
    PLoS One  2014;5:3145

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