Chemical Name: N-[3-[[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]benzamide
Biological ActivityGSK 269962 is a potent Rho kinase (ROCK) inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively). Displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. Induces vasorelaxation in preconstricted rat aorta (IC50 = 35 nM); lowers blood pressure in a rat model of hypertension.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities.
Doe et al.
Discovery of aminofurazan-azabenzimidazoles as inhibitors of Rho-kinase with high kinase selectivity and antihypertensive activity.
Stavenger et al.
Citations for GSK 269962
The citations listed below are publications that use Tocris products. Selected citations for GSK 269962 include:
6 Citations: Showing 1 - 6
Determining the contents and cell origins of apoptotic bodies by flow cytometry.
Authors: Jiang Et al.
Sci Rep 2017;7:14444
A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor.
Authors: Lotz-Jenne Et al.
Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation
Authors: Han Et al.
Planar cell polarity aligns osteoblast division in response to substrate strain.
Authors: Galea Et al.
Stem Cell Res Ther 2015;30:423
Lipopolysaccharide promotes contraction of uterine myocytes via activation of Rho/ROCK signaling pathways.
Authors: Hutchinson Et al.
FASEB J 2014;28:94
G Protein and β-arrestin signaling bias at the ghrelin receptor.
Authors: Evron Et al.
J Biol Chem 2014;289:33442
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