Chemical Name: N-[3-[[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]benzamide
Biological ActivityPotent Rho kinase (ROCK) inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively). Displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. Induces vasorelaxation in preconstricted rat aorta (IC50 = 35 nM); lowers blood pressure in a rat model of hypertension.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Discovery of aminofurazan-azabenzimidazoles as inhibitors of Rho-kinase with high kinase selectivity and antihypertensive activity.
Stavenger et al.
Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities.
Doe et al.
Citations for GSK 269962
The citations listed below are publications that use Tocris products. Selected citations for GSK 269962 include:
5 Citations: Showing 1 - 5
A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor.
Authors: Lotz-Jenne Et al.
Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation
Authors: Han Et al.
Planar cell polarity aligns osteoblast division in response to substrate strain.
Authors: Galea Et al.
Stem Cell Res Ther 2015;30:423
Lipopolysaccharide promotes contraction of uterine myocytes via activation of Rho/ROCK signaling pathways.
Authors: Hutchinson Et al.
FASEB J 2014;28:94
G Protein and β-arrestin signaling bias at the ghrelin receptor.
Authors: Evron Et al.
J Biol Chem 2014;289:33442
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