Biological Activity Potent Rho kinase (ROCK) inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively). Displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. Induces vasorelaxation in preconstricted rat aorta (IC50 = 35 nM); lowers blood pressure in a rat model of hypertension.
Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
Store at +4°C
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For batch specific data refer to the Certificate of Analysis.
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Sold for research purposes under agreement from GlaxoSmithKline.
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