Catalog Number: 4009
Chemical Name: N-[3-[[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]benzamide
Biological Activity
Potent Rho kinase (ROCK) inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively). Displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. Induces vasorelaxation in preconstricted rat aorta (IC50 = 35 nM); lowers blood pressure in a rat model of hypertension.
Technical Data
  • M.Wt:
    570.6
  • Formula:
    C29H30N8O5
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    850664-21-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline.
Background References
  1. Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities.
    Doe et al.
    J.Pharmacol.Exp.Ther., 2007;320:89
  2. Discovery of aminofurazan-azabenzimidazoles as inhibitors of Rho-kinase with high kinase selectivity and antihypertensive activity.
    Stavenger et al.
    J.Med.Chem., 2007;50:2
Citations:

The citations listed below are publications that use Tocris products. Selected citations for GSK 269962 include:

2 Citations: Showing 1 - 2
Filter your results:

  1. Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation
    Authors: Han Et al.
    Nature 2016;539:570
  2. Planar cell polarity aligns osteoblast division in response to substrate strain.
    Authors: Galea Et al.
    Stem Cell Res Ther 2015;30:423

Have you used GSK 269962?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information