GSK 269962

Catalog # Availability Size / Price Qty
4009/10
4009/50
Cat.No. 4009 - GSK 269962 | C29H30N8O5 | CAS No. 850664-21-0
1 Image
Description: Potent and selective ROCK inhibitor

Chemical Name: N-[3-[[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]benzamide

Purity: ≥99%

Product Details
Citations (5)
Reviews

Biological Activity

Potent Rho kinase (ROCK) inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively). Displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. Induces vasorelaxation in preconstricted rat aorta (IC50 = 35 nM); lowers blood pressure in a rat model of hypertension.

Technical Data

M.Wt:
570.6
Formula:
C29H30N8O5
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
850664-21-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline.

Product Datasheets

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Citations for GSK 269962

The citations listed below are publications that use Tocris products. Selected citations for GSK 269962 include:

5 Citations: Showing 1 - 5

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