GSK 269962

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4009/10
4009/50

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GSK 269962 | CAS No. 850664-21-0 | Rho-kinase Inhibitors
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Description: Potent and selective ROCK inhibitor

Chemical Name: N-[3-[[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]benzamide

Purity: ≥99%

Product Details
Citations (12)
Reviews

Biological Activity

GSK 269962 is a potent Rho kinase (ROCK) inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively). Displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. Induces vasorelaxation in preconstricted rat aorta (IC50 = 35 nM); lowers blood pressure in a rat model of hypertension.

Technical Data

M.Wt:
570.6
Formula:
C29H30N8O5
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
850664-21-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline.

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Citations for GSK 269962

The citations listed below are publications that use Tocris products. Selected citations for GSK 269962 include:

12 Citations: Showing 1 - 10

  1. Microglia-containing cerebral organoids derived from induced pluripotent stem cells for the study of neurological diseases.
    Authors: Yiling Et al.
    iScience  2023;26:106267
  2. Oncogenic Signaling Alters Cell Shape and Mechanics to Facilitate Cell Division under Confinement.
    Authors: Buzz Et al.
    Dev Cell  2020;52:563-573.e3
  3. A Whole Genome-Wide Arrayed CRISPR Screen in Primary Organ Fibroblasts to Identify Regulators of Kidney Fibrosis.
    Authors: Hauke Et al.
    SLAS Discov  2020;25:591-604
  4. Extracellular matrix anisotropy is determined by TFAP2C-dependent regulation of cell collisions.
    Authors: Stefan Et al.
    Nat Mater  2020;19:227-238
  5. Chemically induced neurite-like outgrowth reveals a multicellular network function in patient-derived glioblastoma cells.
    Authors: Simon J Et al.
    J Cell Sci  2019;132
  6. Methods for High-throughput Drug Combination Screening and Synergy Scoring.
    Authors: Jing Et al.
    Methods Mol Biol  2018;1711:351-398
  7. Determining the contents and cell origins of apoptotic bodies by flow cytometry.
    Authors: Jiang Et al.
    Sci Rep  2017;7:14444
  8. A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor.
    Authors: Lotz-Jenne Et al.
    Oncotarget  2016;7:25983
  9. Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation
    Authors: Han Et al.
    Nature  2016;539:570
  10. Planar cell polarity aligns osteoblast division in response to substrate strain.
    Authors: Galea Et al.
    Stem Cell Res Ther  2015;30:423

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