GSK 269962

  ( 5 citations )    
Product Datasheet
Catalog Number:4009
Chemical Name:N-[3-[[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]benzamide
Product Details
Citations (5)
Reviews
Biological Activity
Potent Rho kinase (ROCK) inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively). Displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. Induces vasorelaxation in preconstricted rat aorta (IC50 = 35 nM); lowers blood pressure in a rat model of hypertension.
Technical Data
  • M.Wt:
    570.6
  • Formula:
    C29H30N8O5
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    850664-21-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for GSK 269962 include:

5 Citations: Showing 1 - 5
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  1. A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor.
    Authors: Lotz-Jenne Et al.
    Oncotarget  2016;7:25983
  2. Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation
    Authors: Han Et al.
    Nature  2016;539:570
  3. Planar cell polarity aligns osteoblast division in response to substrate strain.
    Authors: Galea Et al.
    Stem Cell Res Ther  2015;30:423
  4. Lipopolysaccharide promotes contraction of uterine myocytes via activation of Rho/ROCK signaling pathways.
    Authors: Hutchinson Et al.
    FASEB J  2014;28:94
  5. G Protein and β-arrestin signaling bias at the ghrelin receptor.
    Authors: Evron Et al.
    J Biol Chem  2014;289:33442

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