GSK 319347A

Catalog # Availability Size / Price Qty
5672/10
GSK 319347A | CAS No. 862812-98-4 | IkB Kinase Inhibitors
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Description: Potent and selective IKKε inhibitor

Chemical Name: 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile

Purity: ≥98%

Product Details
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Biological Activity

GSK 319347A is a potent and selective IKKε inhibitor (pIC50 = 7.4). Exhibits >100-fold selectivity for IKKε over IKKα IKKβ, and a range of other kinases.

Technical Data

M.Wt:
469.53
Formula:
C22H19N3O5S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
862812-98-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. 5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase.
    Bamborough et al.
    Bioorg.Med.Chem.Lett., 2006;16:6236

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