Biological Activity Potent RIP2 kinase inhibitor (IC50 values are 2 and 5 nM at rat and human kinases, respectively). Displays selectivity for RIP2K over p38α, VEGFR2 and a panel of 300 kinases. Exhibits some inhibition at BRK and Aurora A. Also displays similar binding affinity, but no detectable functional activity at RIP3. Active in vivo. Moderately orally bioavailable and cell permeable.
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Store at +4°C
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For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
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