GSK 626616

Catalog # Availability Size / Price Qty
6638/50
6638/10
Cat.No. 6638 - GSK 626616 | C18H10Cl2N4OS | CAS No. 1025821-33-3
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Description: Potent and selective DYRK inhibitor; orally bioavailable

Chemical Name: (5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone

Purity: ≥98%

Product Details
Reviews

Biological Activity

Potent and selective DYRK inhibitor (IC50 = 0.7 nM for DYRK3, similar potency for DYRK1 and 2). Exhibits ~20-fold selectivity over casein kinase 2 and negligible activity against a panel of 451 kinases screened. Enhances number of CFU-E stimulated by Epo from human marrow. Increases hemoglobin levels in anemic mice. Orally bioavailable.

Technical Data

M.Wt:
401.27
Formula:
C18H10Cl2N4OS
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1025821-33-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling.
    Wippich et al.
    Cell, 2013;152:791
  2. Kinase-controlled phase transition of membraneless organelles in mitosis.
    Rai et al.
    Nature, 2018;559:211
  3. GSK626616: A DYRK3 inhibitor as a potential new therapy for the treatment of anemia.
    Erickson-Miller et al.
    Blood, 2007;110:510

Product Datasheets

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