GSK 6853

Tocris Bioscience | Catalog # 6198

Potent and selective BRPF1 inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective BRPF1 inhibitor
View all Bromodomain Inhibitors »

Product Description

GSK 6853 is a potent and selective BRPF1 inhibitor. Exhibits >1600-fold selectivity for BRPF1 over other bromodomains (pIC50 values by TR-FRET are 8.1, 5.1/4.8 and 4.7/<4.3 for BRPF1, BRPF2/3 and BRD4 BD1/2, respectively).

Negative Control also available.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the GSK 6853 probe summary on the SGC website.

Product Specifications for GSK 6853

Molecular Weight

409.48

Formula

C22H27N5O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[2,3-dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-2-methoxybenzamide

CAS Number

1910124-24-1

PubChem ID

121232405

InChI Key

FQWDVNSBYDXPIO-CQSZACIVSA-N

SMILES

COC1=C(C(NC2=C(N3CCNC[C@H]3C)C=C4N(C(N(C4=C2)C)=O)C)=O)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 40.95 100
DMSO 40.95 100

Preparing Stock Solutions for GSK 6853

The following data is based on the product molecular weight 409.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.21 mL 24.42 mL
5 mM 0.49 mL 2.44 mL 4.88 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for GSK 6853

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GSK 6853

For research use only

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