Guanfacine hydrochloride

Key Product Details

Product Description

Guanfacine hydrochloride is a selective α_2A-adrenoceptor agonist (K_d = 31 nM). Displays 60-fold selectivity over α_2B-adrenoceptors.

Product Specifications for Guanfacine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Guanfacine hydrochloride

The following data is based on the product molecular weight 282.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.54 mL	17.70 mL	35.39 mL
5 mM	0.71 mL	3.54 mL	7.08 mL
10 mM	0.35 mL	1.77 mL	3.54 mL
50 mM	0.07 mL	0.35 mL	0.71 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 15 publications citing the usage of this product.

• Uhlen and Wikberg Delineation of rat kidney α_2A- and α_2B-adrenoceptors with [³H]RX821002 radioligand binding: computer modelling reveals that guanf. is an α_2A -selective compound. Eur.J.Pharmacol. 1991 PMID: 1666366
• Intengan and Smyth Alpha-2a/d adrenoceptor subtype stimulation by guanf. increases osmolar clearance. J.Pharmacol.Exp.Ther. 1997 PMID: 9103479

Product Documents for Guanfacine hydrochloride