Catalog Number: 1030
Chemical Name: [(2,6-Dichlorophenyl)acetyl]guanidine hydrochloride
Biological Activity
Selective α2A-adrenoceptor agonist (Kd = 31 nM). Displays 60-fold selectivity over α2B-adrenoceptors. Also available as part of the α2-Adrenoceptor Tocriset™.
Technical Data
  • M.Wt:
    282.56
  • Formula:
    C9H9Cl2N3O.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    29110-48-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Alpha-2a/d adrenoceptor subtype stimulation by guanfacine increases osmolar clearance.
    Intengan and Smyth
    J.Pharmacol.Exp.Ther., 1997;281:48
  2. Delineation of rat kidney α2A- and α2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanfacine is an α2A -selective compound.
    Uhlen and Wikberg
    Eur.J.Pharmacol., 1991;202:235
  3. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Guanfacine hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Neuritin can normalize neural deficits of Alzheimer's disease.
    Authors: An Et al.
    Cell Death Dis 2014;5:e1523
  2. Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors.
    Authors: Hamby Et al.
    Pharmacol Res Perspect 2012;32:14489

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