GUCY2C Antibody [ADC] - (Indusatumab Vedotin, Research Grade)

Novus Biologicals | Catalog # NBP3-44535

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Functional

Label

ADC

Antibody Source

Monoclonal Human IgG1
View all Guanylyl Cyclase C/GUCY2C Primary Antibodies »

Product Specifications

Immunogen

Guanylyl Cyclase C/GUCY2C (Uniprot: P25092)

Clonality

Monoclonal

Host

Human

Isotype

IgG1

Theoretical MW

150.45 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

This product is an Antibody-Drug Conjugate (ADC) for Research Use Only (RUO).

Indusatumab vedotin is an antibody-drug conjugate that is under development for the treatment of pancreatic cancer and other gastrointestinal cancers. It consists of a monoclonal antibody (indusatumab) that targets the enzyme guanylate cyclase 2C which is present in some cancers, linked to an average of three to four molecules of the chemotherapeutic agent monomethyl auristatin E (MMAE).

This product is shipped at ambient temperature. Upon receipt, store immediately at -20C or lower for 12 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.

Scientific Data Images for GUCY2C Antibody [ADC] - (Indusatumab Vedotin, Research Grade)

Hu GUCY2C mAb [ADC] - (Indusatumab Vedotin)

ELISA: Hu GUCY2C mAb [ADC] - (Indusatumab Vedotin) [NBP3-44535]

Immobilized Human Guanylyl Cyclase C/GUCY2C, His Tag at 2 ug/mL can bind Guanylyl Cyclase C/Guanylyl Cyclase C/GUCY2C, EC50 is 0.01160 ug/mL.
Hu GUCY2C mAb [ADC] - (Indusatumab Vedotin)

Flow Cytometry: Hu GUCY2C mAb [ADC] - (Indusatumab Vedotin) [NBP3-44535]

Human Guanylyl Cyclase C/GUCY2C CHO Cell Line were stained with Guanylyl Cyclase C/Guanylyl Cyclase C/GUCY2C and negative control protein respectively, washed and then followed by PE and analyzed with FACS,The EC50 is 0.05 mug/mL.

Applications for GUCY2C Antibody [ADC] - (Indusatumab Vedotin, Research Grade)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Functional

Optimal dilutions of this antibody should be experimentally determined.

Spectra Viewer

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

Spectra Viewer
Spectra Viewer

Flow Cytometry Panel Builder

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Save time and reduce costly mistakes by quickly finding compatible reagents using the Panel Builder Tool.

Advanced Features

  • Spectra Viewer - Custom analysis of spectra from multiple fluorochromes
  • Spillover Popups - Visualize the spectra of individual fluorochromes
  • Antigen Density Selector - Match fluorochrome brightness with antigen density
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Flow Cytometry

Formulation, Preparation, and Storage

Purification

> 90% by SDS-PAGE and HPLC

Reconstitution

Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Formulation

Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C in powder form. Store at -80C once reconstituted.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Guanylyl Cyclase C/GUCY2C

Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin.

Alternate Names

DIAR6, GC-C, GCC, Guanylate Cyclase C, GUC2C, GUCY2C, MUCIL, STA Receptor, StAR

Additional Guanylyl Cyclase C/GUCY2C Products

Product Documents for GUCY2C Antibody [ADC] - (Indusatumab Vedotin, Research Grade)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for GUCY2C Antibody [ADC] - (Indusatumab Vedotin, Research Grade)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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