Chemical Name: [4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]acetic acid
Biological ActivityPotent and highly selective PPARδ agonist. EC50 values are 0.001, 1.1 and 2 μM for transactivation of human PPARδ, -α, and -γ receptors respectively. Neuroprotective in rat cerebellar granule neuronal cultures after brief (12-hour) exposure but exhibits inherent toxicity after prolonged (48-hour) incubation. Increases rate of fatty acid oxidation and protects against ischemia/reperfusion injury in neonatal and adult cardiomyocytes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ) - Synthesis and biological activity.
Sznaidman et al.
Effect of the peroxisome proliferator-activated receptor β activator GW0742 in rat cultured cerebellar granule neurons.
Smith et al.
In vivo activation of peroxisome proliferator-activayed receptor-δ protects the heart from ischemia/reperfusion injury in Zucker fatty rats.
Yue et al.
Citations for GW 0742
The citations listed below are publications that use Tocris products. Selected citations for GW 0742 include:
10 Citations: Showing 1 - 10
PPARD is an Inhibitor of Cartilage Growth in External Ears
Int J Biol Sci 2017;13(5):669
Development of PPAR-agonist GW0742 as antidiabetic drug: study in animals.
Authors: Niu Et al.
Invest Ophthalmol Vis Sci 2015;9:5625
Peroxisomes in Different Skeletal Cell Types during Intramembranous and Endochondral Ossification and Their Regulation during Osteoblast Differentiation by Distinct Peroxisome Proliferator-Activated Receptors.
Authors: Qian Et al.
PLoS One 2015;10:e0143439
The coactivator PGC-1α regulates skeletal muscle oxidative metabolism independently of the nuclear receptor PPARβ/δ in sedentary mice fed a regular chow diet.
Authors: Perez-Schindler Et al.
Modulation of Transcription mediated by the Vitamin D Receptor and the Peroxisome Proliferator-Activated Receptor δ in the presence of GW0742 analogs.
Authors: Teske Et al.
Drug Des Devel Ther 2014;3
Decrease of PPARδ in Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord Injury.
Authors: Tsai Et al.
PPAR Res 2014;2014:456386
Peroxisome proliferator-activated receptor-β/δ regulates angiogenic cell behaviors and oxygen-induced retinopathy.
Authors: Capozzi Et al.
J Allergy Clin Immunol 2013;54:4197
Structural insights into human peroxisome proliferator activated receptor delta (PPAR-delta) selective ligand binding.
Authors: Batista Et al.
PLoS One 2012;7:e33643
PPARδ activation protects endothelial function in diabetic mice.
Authors: Tian Et al.
Murine atopic dermatitis responds to peroxisome proliferator-activated receptors α and β/δ (but not γ) and liver X receptor activators.
Authors: Hatano Et al.
PLoS One 2010;125:160
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