GW 0742

  ( 8 citations )    
Product Datasheet
Catalog Number:2229
Chemical Name:[4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]acetic acid
Product Details
Citations (8)
Supplemental Products
Reviews
Biological Activity
Potent and highly selective PPARδ agonist. EC50 values are 0.001, 1.1 and 2 μM for transactivation of human PPARδ, -α, and -γ receptors respectively. Neuroprotective in rat cerebellar granule neuronal cultures after brief (12-hour) exposure but exhibits inherent toxicity after prolonged (48-hour) incubation. Increases rate of fatty acid oxidation and protects against ischemia/reperfusion injury in neonatal and adult cardiomyocytes.
Technical Data
  • M.Wt:
    471.49
  • Formula:
    C21H17F4NO3S2
  • Solubility:
    Soluble to 50 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at +4°C
  • CAS No:
    317318-84-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for GW 0742 include:

8 Citations: Showing 1 - 8
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  1. PPARD is an Inhibitor of Cartilage Growth in External Ears
    Authors: Zhang
    Int J Biol Sci  2017;13(5):669
  2. Development of PPAR-agonist GW0742 as antidiabetic drug: study in animals.
    Authors: Niu Et al.
    Invest Ophthalmol Vis Sci  2015;9:5625
  3. Peroxisomes in Different Skeletal Cell Types during Intramembranous and Endochondral Ossification and Their Regulation during Osteoblast Differentiation by Distinct Peroxisome Proliferator-Activated Receptors.
    Authors: Qian Et al.
    PLoS One  2015;10:e0143439
  4. The coactivator PGC-1α regulates skeletal muscle oxidative metabolism independently of the nuclear receptor PPARβ/δ in sedentary mice fed a regular chow diet.
    Authors: Perez-Schindler Et al.
    Diabetologia  2014;57:2405
  5. Modulation of Transcription mediated by the Vitamin D Receptor and the Peroxisome Proliferator-Activated Receptor δ in the presence of GW0742 analogs.
    Authors: Teske Et al.
    Drug Des Devel Ther  2014;3
  6. Peroxisome proliferator-activated receptor-β/δ regulates angiogenic cell behaviors and oxygen-induced retinopathy.
    Authors: Capozzi Et al.
    J Allergy Clin Immunol  2013;54:4197
  7. PPARδ activation protects endothelial function in diabetic mice.
    Authors: Tian Et al.
    Diabetes  2012;61:3285
  8. Murine atopic dermatitis responds to peroxisome proliferator-activated receptors α and β/δ (but not γ) and liver X receptor activators.
    Authors: Hatano Et al.
    PLoS One  2010;125:160

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