Chemical Name: [4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]acetic acid
Biological ActivityGW 0742 is a potent and highly selective PPARδ agonist. EC50 values are 0.001, 1.1 and 2 μM for transactivation of human PPARδ, -α, and -γ receptors respectively. Neuroprotective in rat cerebellar granule neuronal cultures after brief (12-hour) exposure but exhibits inherent toxicity after prolonged (48-hour) incubation. Increases rate of fatty acid oxidation and protects against ischemia/reperfusion injury in neonatal and adult cardiomyocytes.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ) - Synthesis and biological activity.
Sznaidman et al.
Effect of the peroxisome proliferator-activated receptor β activator GW0742 in rat cultured cerebellar granule neurons.
Smith et al.
In vivo activation of peroxisome proliferator-activayed receptor-δ protects the heart from ischemia/reperfusion injury in Zucker fatty rats.
Yue et al.
Citations for GW 0742
The citations listed below are publications that use Tocris products. Selected citations for GW 0742 include:
14 Citations: Showing 1 - 10
Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties.
Authors: Smith Et al.
Psychopharmacology (Berl) 2019;
PPARδ Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth.
Authors: Martín-Martín Et al.
Cancer Res 2018;78:399
Retinoic acid inhibits white adipogenesis by disrupting GADD45A-mediated Zfp423 DNA demethylation.
Authors: Wang Et al.
J Mol Cell Biol 2017;9:338
Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation.
Authors: Halstead Et al.
PPARD is an Inhibitor of Cartilage Growth in External Ears
Int J Biol Sci 2017;13(5):669
Development of PPAR-agonist GW0742 as antidiabetic drug: study in animals.
Authors: Niu Et al.
Invest Ophthalmol Vis Sci 2015;9:5625
Peroxisomes in Different Skeletal Cell Types during Intramembranous and Endochondral Ossification and Their Regulation during Osteoblast Differentiation by Distinct Peroxisome Proliferator-Activated Receptors.
Authors: Qian Et al.
PLoS One 2015;10:e0143439
The coactivator PGC-1α regulates skeletal muscle oxidative metabolism independently of the nuclear receptor PPARβ/δ in sedentary mice fed a regular chow diet.
Authors: Perez-Schindler Et al.
Modulation of Transcription mediated by the Vitamin D Receptor and the Peroxisome Proliferator-Activated Receptor δ in the presence of GW0742 analogs.
Authors: Teske Et al.
Drug Des Devel Ther 2014;3
Decrease of PPARδ in Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord Injury.
Authors: Tsai Et al.
PPAR Res 2014;2014:456386
Peroxisome proliferator-activated receptor-β/δ regulates angiogenic cell behaviors and oxygen-induced retinopathy.
Authors: Capozzi Et al.
J Allergy Clin Immunol 2013;54:4197
Structural insights into human peroxisome proliferator activated receptor delta (PPAR-delta) selective ligand binding.
Authors: Batista Et al.
PLoS One 2012;7:e33643
PPARδ activation protects endothelial function in diabetic mice.
Authors: Tian Et al.
Murine atopic dermatitis responds to peroxisome proliferator-activated receptors α and β/δ (but not γ) and liver X receptor activators.
Authors: Hatano Et al.
PLoS One 2010;125:160
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