Potent and highly selective PPARδ
values are 0.001, 1.1 and 2 μ
M for transactivation of human PPARδ
, and -γ
receptors respectively. Neuroprotective in rat cerebellar granule neuronal cultures after brief (12-hour) exposure but exhibits inherent toxicity after prolonged (48-hour) incubation. Increases rate of fatty acid oxidation and protects against ischemia/reperfusion injury in neonatal and adult cardiomyocytes.
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Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ) - Synthesis and biological activity.
Sznaidman et al.
Effect of the peroxisome proliferator-activated receptor β activator GW0742 in rat cultured cerebellar granule neurons.
Smith et al.
In vivo activation of peroxisome proliferator-activayed receptor-δ protects the heart from ischemia/reperfusion injury in Zucker fatty rats.
Yue et al.
The citations listed below are publications that use Tocris products. Selected citations for GW 0742 include:
Showing Results 1 - 6 of 6