GW 1929 hydrochloride (CAS 1217466-21-1): R&D Systems
Catalog Number: 1664
Chemical Name: N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine hydrochloride
Biological Activity
Highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist (pEC50 values are 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors respectively). Decreases glucose, fatty acid and triglyceride levels following oral administration in vivo.
Technical Data
  • M.Wt:
    532.03
  • Formula:
    C30H29N3O4.HCl
  • Solubility:
    Soluble to 100 mM in ethanol with gentle warming and to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    1217466-21-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline
Background References
  1. A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-γ reverses the diabetic phenotype of the Zucker diabetic fatty rat.
    Brown et al.
    Diabetes, 1999;48:1415
  2. Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor γ agonists.
    Way et al.
    J.Biol.Chem., 2001;276:25651
  3. Potentiation of glucose uptake in 3T3-L1 adipocytes by PPARγ agonists is maintained in cells expressing a PPARγ dominant-negative mutant: evidence for selectivity in the downstream responses to PPARγ activation.
    Nugent et al.
    Mol.Endocrinol., 2001;15:1729
Citations:

The citations listed below are publications that use Tocris products. Selected citations for GW 1929 hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Nicotinic acid receptor GPR109A is down-regulated in human macrophage-derived foam cells.
    Authors: Chai Et al.
    PLoS One 2013;8:e62934
  2. Murine atopic dermatitis responds to peroxisome proliferator-activated receptors α and β/δ (but not γ) and liver X receptor activators.
    Authors: Hatano Et al.
    Endocrinology 2010;125:160

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