GW 4869

Catalog # Availability Size / Price Qty
6741/10
GW 4869 | Hydrolase Inhibitors
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Description: Selective neutral sphingomyelin phosphodiesterase (N-SMase) inhibitor

Chemical Name: 3,3'-(1,4-Phenylene)bis[N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-2-propenamide] ditrifluoroacetate

Purity: ≥90%

Product Details
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Biological Activity

Selective neutral sphingomyelin phosphodiesterase (N-SMase) inhibitor (IC50 = 1 μM). Exhibits selectivity for neutral sphingomyelinase over acid sphingomyelinase (a-SMase) at concentrations up to 150 μM as well as B. cereus PC-PLC, human lyso-PAF PLC, and bovine PP2A at 10 μM. Blocks exosome biogenesis. Inhibits TNF-α-induced sphingomyelin hydrolysis and TNF-α-induced cell death in MCF-7 cells. Reverses hypoxia-induced pulmonary vasoconstriction in rats. Neuroprotective.

Technical Data

M.Wt:
732.64
Formula:
C30H28N6O2.2CF3COOH
Solubility:
Soluble to 2 mM in DMSO
Purity:
≥90%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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