Chemical Name: 2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic acid
Biological ActivityPotent and selective PPARδ agonist (EC50 = 1.2 nM). Displays <1000-fold selectivity over other PPAR subtypes. Increases ABC A1 transporter expression and induces apolipoprotein A1-mediated cholesterol efflux in vitro. Also increase serum HDL cholesterol and lowers small, dense LDL levels in obesity in vivo models.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport.
Oliver et al.
Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance.
Ito et al.
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VersaClone cDNA Plasmids
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