Catalog Number: 5674
Chemical Name: 2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic acid
Biological Activity
Potent and selective PPARδ agonist (EC50 = 1.2 nM). Displays <1000-fold selectivity over other PPAR subtypes. Increases ABC A1 transporter expression and induces apolipoprotein A1-mediated cholesterol efflux in vitro. Also increase serum HDL cholesterol and lowers small, dense LDL levels in obesity in vivo models.
Technical Data
  • M.Wt:
    453.5
  • Formula:
    C21H18F3NO3S2
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    317318-70-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport.
    Oliver et al.
    Proc.Natl.Acad.Sci.USA., 2001;98:5306
  2. Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance.
    Ito et al.
    Science, 2016;354:1156

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