Chemical Name: 2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic acid
Biological ActivityGW 501516 is a potent and selective PPARδ agonist (EC50 = 1.2 nM). Displays <1000-fold selectivity over other PPAR subtypes. Increases ABC A1 transporter expression and induces apolipoprotein A1-mediated cholesterol efflux in vitro. Also increase serum HDL cholesterol and lowers small, dense LDL levels in obesity in vivo models.
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A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport.
Oliver et al.
Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance.
Ito et al.
Citation for GW 501516
The citations listed below are publications that use Tocris products. Selected citations for GW 501516 include:
1 Citation: Showing 1 - 1
Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis.
Authors: Guo Et al.
Nat Med 2018;24:360
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