Potent and selective PPARδ
= 1.2 nM). Displays <1000-fold selectivity over other PPAR subtypes. Increases ABC A1 transporter expression and induces apolipoprotein A1-mediated cholesterol efflux in vitro
. Also increase serum HDL cholesterol and lowers small, dense LDL levels in obesity in vivo
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A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport.
Oliver et al.