GW 5074

  ( 7 citations )    
Product Datasheet
Catalog Number:1381
Chemical Name:3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one
Product Details
Citations (7)
Reviews
Biological Activity
Potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC50 = 9 nM). Displays ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm.
Technical Data
  • M.Wt:
    520.94
  • Formula:
    C15H8Br2INO2
  • Solubility:
    Soluble to 1 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    220904-83-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Glaxo Wellcome Inc and Glaxo Group Ltd.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for GW 5074 include:

7 Citations: Showing 1 - 7
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  1. Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments.
    Authors: Li Et al.
    PLoS One  2013;13:1969
  2. Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease.
    Authors: Cooper Et al.
    Sci Transl Med  2012;4:141ra90
  3. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem  2011;116:984
  4. A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors.
    Authors: Schaertl Et al.
    J Biomol Screen  2010;15:478
  5. Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract.
    Authors: Kim Et al.
    Exp Mol Med  2009;41:277
  6. Signaling of short- and long-term regulation of intestinal epithelial type 1 Na+/H+ exchanger by interferon-gamma.
    Authors: Magro Et al.
    Br J Pharmacol  2005;145:93
  7. Intestinal Na+-K+-ATPase activity and molecular events downstream of interferon-gamma receptor stimulation.
    Authors: Magro Et al.
    Br J Pharmacol  2004;142:1281

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