GW 5074

Catalog # Availability Size / Price Qty
1381/10
1381/50

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GW 5074 | CAS No. 220904-83-6 | Raf Kinase Inhibitors
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Description: Potent, selective c-Raf1 kinase inhibitor

Chemical Name: 3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one

Purity: ≥98%

Product Details
Citations (7)
Reviews

Biological Activity

GW 5074 is a potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC50 = 9 nM). GW 5074 displays ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. GW 5074 binds mutant huntingtin (mHTT) and decreases levels of mHTT in cultured hippocampal neurons and fibroblasts from patients with Huntington's disease. Brain penetrant.

Technical Data

M.Wt:
520.94
Formula:
C15H8Br2INO2
Solubility:
Soluble to 1 mM in ethanol and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
220904-83-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Glaxo Wellcome Inc and Glaxo Group Ltd.

Product Datasheets

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Citations for GW 5074

The citations listed below are publications that use Tocris products. Selected citations for GW 5074 include:

7 Citations: Showing 1 - 7

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