Activator of small-conductance Ca2+
2); selective for KCa
= 8.2 μ
M in HEK293 cells expressing hKCa
2.1) with the profile hKCa
2.1 > hKCa
2.2 = hKCa
2.3 > hKCa
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Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methyoxy-phenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 298 in
Hougaard et al.