GW 6471

Tocris Bioscience | Catalog # 4618

PPARα antagonist
Tocris Bioscience

Key Product Details

Description

PPARα antagonist
View all PPAR alpha Receptor Antagonists »

Product Description

GW 6471 is a PPARα antagonist (IC50 = 0.24 μM). GW 6471 enhances the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR. GW 6471 blocks SARS-CoV-2 infection in airway organoids (EC50 = 2.1 μM) by blocking and downregulating the hypoxia inducible factor 1 subunit alpha (HIF1α) and HIF1 pathway; also reduces viral RNA. GW 6471 induces apoptosis and cell cycle arrest in kidney cancer cells.

Licensing Information

Sold with the permission of GlaxoSmithKline.

Product Specifications for GW 6471

Molecular Weight

619.67

Formula

C35H36F3N3O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-((2S)-2-(((1Z)-1-Methyl-3-oxo-3-(4-(trifluoromethyl)phenyl)prop-1-enyl)amino)-3-(4-(2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy)phenyl)propyl)propanamide

CAS Number

880635-03-0

PubChem ID

446738

InChI Key

TYEFSRMOUXWTDN-DYQICHDWSA-N

SMILES

CC2=C(N=C(C4=CC=CC=C4)O2)CCOC(C=C1)=CC=C1C[C@@H](CNC(CC)=O)N/C(C)=C\C(C3=CC=C(C(F)(F)F)C=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.48 75
Ethanol 6.2 10

Preparing Stock Solutions for GW 6471

The following data is based on the product molecular weight 619.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 2.15 mL 10.76 mL 21.52 mL
3.75 mM 0.43 mL 2.15 mL 4.30 mL
7.5 mM 0.22 mL 1.08 mL 2.15 mL
37.5 mM 0.04 mL 0.22 mL 0.43 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 126 publications citing the usage of this product.

Product Documents for GW 6471

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GW 6471

For research use only

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