Chemical Name: 2-[[4-[2-[[(Cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-2-methylpropanoic acid
Biological ActivityGW 7647 is a potent and highly selective PPARα agonist (EC50 values are 6, 1100 and 6200 nM for human PPARα, PPARγ and PPARδ receptors respectively). Modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubules in vitro. Has lipid-lowering effects following oral administration in vivo. Reduces NO production in macrophages; exhibits anti-inflammatory properties.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors.
Cunard et al.
Identification of a subtype selective human PPARα agonist through parallel-array synthesis.
Brown et al.
PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages.
Paukkeri et al.
Peroxisome proliferator-activated receptor-α regulates fatty acid utilization in primary human skeletal muscle cells.
Muoio et al.
Citations for GW 7647
The citations listed below are publications that use Tocris products. Selected citations for GW 7647 include:
8 Citations: Showing 1 - 8
Phytocannabinoids promote viability and functional adipogenesis of bone marrow-derived mesenchymal stem cells through different molecular targets
Authors: Fellous Et al.
Biochemical Pharmacology 2020;175
Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis.
Authors: Guo Et al.
Nat Med 2018;24:360
Metabolic Profiling of Chicken Embryos Exposed to Perfluorooctanoic Acid (PFOA) and Agonists to Peroxisome Proliferator-Activated Receptors.
Authors: Mattsson Et al.
PLoS One 2015;10:e0143780
Computational and biological evaluation of N-octadecyl-N'-propylsulfamide, a selective PPARα agonist structurally related to N-acylethanolamines.
Authors: Moreno-Santos Et al.
PLoS One 2014;9:e92195
Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery.
Authors: Yu Et al.
J Allergy Clin Immunol 2013;21:4266
Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply.
Authors: Mottillo Et al.
Bioorg Med Chem 2012;287:25038
Murine atopic dermatitis responds to peroxisome proliferator-activated receptors α and β/δ (but not γ) and liver X receptor activators.
Authors: Hatano Et al.
Cell Commun Signal 2010;125:160
Rapid non-genomic regulation of Ca2+ signals and Ins secretion by PPAR alpha ligands in mouse pancreatic islets of Langerhans.
Authors: Ropero Et al.
J Endocrinol 2009;200:127
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GW7647 is the most potent PPARalpha agonist that reduces LPS-induced iNOS expression and NO production in macrophages by enhancing iNOS protein degradation through the proteasome pathway. Concentration 3, 10 and 30 uM showed dose-dependent inhibition.