Potent and highly selective PPARα
values are 6, 1100 and 6200 nM for human PPARα
receptors respectively). Modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubules in vitro
. Has lipid-lowering effects following oral administration in vivo
. Reduces NO production in macrophages; exhibits anti-inflammatory properties.
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Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors.
Cunard et al.
Identification of a subtype selective human PPARα agonist through parallel-array synthesis.
Brown et al.
Peroxisome proliferator-activated receptor-α regulates fatty acid utilization in primary human skeletal muscle cells.
Muoio et al.
PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages.
Paukkeri et al.
The citations listed below are publications that use Tocris products. Selected citations for GW 7647 include:
Showing Results 1 - 5 of 5