GW 7647

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1677/50
GW 7647 | CAS No. 265129-71-3 | PPAR alpha Receptor Agonists
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Description: Highly selective, potent PPARα agonist. Orally active

Chemical Name: 2-[[4-[2-[[(Cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-2-methylpropanoic acid

Purity: ≥99%

Product Details
Citations (8)
Supplemental Products
Reviews (1)

Biological Activity

Potent and highly selective PPARα agonist (EC50 values are 6, 1100 and 6200 nM for human PPARα, PPARγ and PPARδ receptors respectively). Modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubules in vitro. Has lipid-lowering effects following oral administration in vivo. Reduces NO production in macrophages; exhibits anti-inflammatory properties.

Technical Data

M.Wt:
502.75
Formula:
C29H46N2O3S
Solubility:
Soluble to 25 mM in ethanol and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
265129-71-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline

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Citations for GW 7647

The citations listed below are publications that use Tocris products. Selected citations for GW 7647 include:

8 Citations: Showing 1 - 8

  1. Phytocannabinoids promote viability and functional adipogenesis of bone marrow-derived mesenchymal stem cells through different molecular targets
    Authors: Fellous Et al.
    Biochemical Pharmacology  2020;175
  2. Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis.
    Authors: Guo Et al.
    Nat Med  2018;24:360
  3. Metabolic Profiling of Chicken Embryos Exposed to Perfluorooctanoic Acid (PFOA) and Agonists to Peroxisome Proliferator-Activated Receptors.
    Authors: Mattsson Et al.
    PLoS One  2015;10:e0143780
  4. Computational and biological evaluation of N-octadecyl-N'-propylsulfamide, a selective PPARα agonist structurally related to N-acylethanolamines.
    Authors: Moreno-Santos Et al.
    PLoS One  2014;9:e92195
  5. Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery.
    Authors: Yu Et al.
    J Allergy Clin Immunol  2013;21:4266
  6. Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply.
    Authors: Mottillo Et al.
    Bioorg Med Chem  2012;287:25038
  7. Murine atopic dermatitis responds to peroxisome proliferator-activated receptors α and β/δ (but not γ) and liver X receptor activators.
    Authors: Hatano Et al.
    Cell Commun Signal  2010;125:160
  8. Rapid non-genomic regulation of Ca2+ signals and Ins secretion by PPAR alpha ligands in mouse pancreatic islets of Langerhans.
    Authors: Ropero Et al.
    J Endocrinol  2009;200:127

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PPAR alpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages.
By GAJANAN KATKAR on 12/07/2019
Application: Species: Mouse

GW7647 is the most potent PPARalpha agonist that reduces LPS-induced iNOS expression and NO production in macrophages by enhancing iNOS protein degradation through the proteasome pathway. Concentration 3, 10 and 30 uM showed dose-dependent inhibition.


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