Selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) (IC50
values are 2.2 and 9.1 nM respectively). Displays > 100-fold selectivity over ~30 other kinases tested including cdk1 and cdk2. Inhibits proliferation of most tumor cells in vitro
and is selective over normal diploid fibroblasts.
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In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1.
Lansing et al.
Mol.Cancer Ther., 2007;6:450
The citations listed below are publications that use Tocris products. Selected citations for GW 843682X include:
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