GW 843682X

Catalog # Availability Size / Price Qty
2977/1
2977/10
2977/50
Cat.No. 2977 - GW 843682X | C22H18F3N3O4S | CAS No. 660868-91-7
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Description: Selective inhibitor of PLK1 and PLK3

Chemical Name: 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide

Purity: ≥98%

Product Details
Citations (9)
Reviews

Biological Activity

Selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) (IC50 values are 2.2 and 9.1 nM respectively). Displays > 100-fold selectivity over ~30 other kinases tested including cdk1 and cdk2. Inhibits proliferation of most tumor cells in vitro and is selective over normal diploid fibroblasts.

Technical Data

M.Wt:
477.46
Formula:
C22H18F3N3O4S
Solubility:
Soluble to 75 mM in DMSO and to 5 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
660868-91-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline

Background References

  1. In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1.
    Lansing et al.
    Mol.Cancer Ther., 2007;6:450

Product Datasheets

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Citations for GW 843682X

The citations listed below are publications that use Tocris products. Selected citations for GW 843682X include:

9 Citations: Showing 1 - 9

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