Potent and selective agonist for the free fatty acid receptor FFA1 (GPR40) (pEC50
values are 7.32, < 4.3 and < 4.3 for FFA1, FFA2 and FFA3 receptors respectively). Inactive against a range of other GPCRs, kinases, proteases, integrins and PPARs. Potentiates glucose-stimulated insulin secretion in MIN6 cells (pEC50
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Synthesis and activity of small molecule GPR40 agonists.
Garrido et al.
Pharmacological regulation of insulin secretion in MIN6 cells through fatty acid receptor GPR40: identification of agonist and antagonist small molecules.
Briscoe et al.
Activation of ATP-sensitive potassium channels in rat pancreatic β-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway.
Zhao and Chen
The citations listed below are publications that use Tocris products. Selected citations for GW 9508 include:
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