Catalog Number: 2649
Chemical Name: 4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid
Biological Activity
Potent and selective agonist for the free fatty acid receptor FFA1 (GPR40) (pEC50 values are 7.32, < 4.3 and < 4.3 for FFA1, FFA2 and FFA3 receptors respectively). Inactive against a range of other GPCRs, kinases, proteases, integrins and PPARs. Potentiates glucose-stimulated insulin secretion in MIN6 cells (pEC50 = 6.14).
Technical Data
  • M.Wt:
    347.41
  • Formula:
    C22H21NO3
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    885101-89-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of GlaxoSmithKline
Background References
  1. Synthesis and activity of small molecule GPR40 agonists.
    Garrido et al.
    Bioorg.Med.Chem.Lett., 2006;16:1840
  2. Pharmacological regulation of insulin secretion in MIN6 cells through fatty acid receptor GPR40: identification of agonist and antagonist small molecules.
    Briscoe et al.
    Br.J.Pharmacol., 2006;148:619
  3. Activation of ATP-sensitive potassium channels in rat pancreatic β-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway.
    Zhao and Chen
    J.Endocrinol., 2008;198:533
Citations:

The citations listed below are publications that use Tocris products. Selected citations for GW 9508 include:

2 Citations: Showing 1 - 2
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  1. Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation.
    Authors: Dragano
    J Neuroinflammation 2017;14(1):91
  2. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects.
    Authors: Oh Et al.
    Cell 2010;142:687

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