GW 9662

  ( 10 citations )    
Product Datasheet
Catalog Number:1508
Chemical Name:2-Chloro-5-nitro-N-phenylbenzamide
Product Details
Citations (10)
Supplemental Products
Reviews
Biological Activity
Selective irreversible PPARγ antagonist (IC50 values are 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively). Blocks the inhibition of osteoclast formation induced by IL-4 in the low micromolar range (1-2 μM), therefore is more potent than BADGE (Cat. No. 1326). Anticancer, inhibits growth of human mammary tumor cell lines.
Technical Data
  • M.Wt:
    276.68
  • Formula:
    C13H9N2O3Cl
  • Solubility:
    Soluble to 25 mM in ethanol with gentle warming and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    22978-25-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for GW 9662 include:

10 Citations: Showing 1 - 10
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  1. Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell Formation.
    Authors: Kotla and Rao
    J Biol Chem  2015;290:30306
  2. Mechanisms of Nifedipine-Downregulated CD40L/sCD40L Signaling in Collagen Stimulated Human Platelets.
    Authors: Chen Et al.
    PLoS One  2015;10:e0127054
  3. Antiplatelet activity of nifedipine is mediated by inhibition of NF-κB activation caused by enhancement of PPAR-β/-γ activity.
    Authors: Shih Et al.
    Br J Pharmacol  2014;171:1490
  4. Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α.
    Authors: Scuderi Et al.
    Arterioscler Thromb Vasc Biol  2012;9:49
  5. Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.
    Authors: Ramachandran Et al.
    J Biol Chem  2012;287:38028
  6. Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply.
    Authors: Mottillo Et al.
    PLoS One  2012;287:25038
  7. Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement.
    Authors: Esposito Et al.
    FASEB J  2011;6:e28668
  8. Antiplatelet actions of statins and fibrates are mediated by PPARs.
    Authors: Ali Et al.
    J Neurosci  2009;29:706
  9. Homocysteine up-regulates vascular transmembrane chemokine CXCL16 and induces CXCR6+ lymphocyte recruitment in vitro and in vivo.
    Authors: Postea Et al.
    J Cell Mol Med  2008;12:1700
  10. Role of nuclear receptor signaling in platelets: antithrombotic effects of PPARβ.
    Authors: Ali Et al.
    J Neuroinflammation  2006;20:326

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