GW 9662

Catalog # Availability Size / Price Qty
1508/10
1508/50
GW 9662 | CAS No. 22978-25-2 | PPAR gamma Receptor Antagonists
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Description: Selective covalent PPARγ antagonist

Chemical Name: 2-Chloro-5-nitro-N-phenylbenzamide

Purity: ≥98%

Product Details
Citations (13)
Supplemental Products
Reviews (2)

Biological Activity

Selective irreversible PPARγ antagonist (IC50 values are 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively). Blocks the inhibition of osteoclast formation induced by IL-4 in the low micromolar range (1-2 μM), therefore is more potent than BADGE (Cat. No. 1326). Anticancer, inhibits growth of human mammary tumor cell lines.

Technical Data

M.Wt:
276.68
Formula:
C13H9N2O3Cl
Solubility:
Soluble to 25 mM in ethanol with gentle warming and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
22978-25-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for GW 9662

The citations listed below are publications that use Tocris products. Selected citations for GW 9662 include:

13 Citations: Showing 1 - 10

  1. Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties.
    Authors: Smith Et al.
    Psychopharmacology (Berl)  2019;
  2. Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis.
    Authors: Guo Et al.
    Nat Med  2018;24:360
  3. Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell Formation.
    Authors: Kotla and Rao
    J Biol Chem  2015;290:30306
  4. Additive Renoprotection by pioglit. and fenofi. against Inflammatory, Oxidative and Apoptotic Manifestations of cisp. Nephrotoxicity: Modulation by PPARs.
    Authors: Helmy Et al.
    PLoS One  2015;10:e0142303
  5. Mechanisms of Nifedipine-Downregulated CD40L/sCD40L Signaling in Collagen Stimulated Human Platelets.
    Authors: Chen Et al.
    PLoS One  2015;10:e0127054
  6. Antiplatelet activity of nifed. is mediated by inhibition of NF-κB activation caused by enhancement of PPAR-β/-γ activity.
    Authors: Shih Et al.
    Br J Pharmacol  2014;171:1490
  7. Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α.
    Authors: Scuderi Et al.
    Arterioscler Thromb Vasc Biol  2012;9:49
  8. Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.
    Authors: Ramachandran Et al.
    J Biol Chem  2012;287:38028
  9. Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply.
    Authors: Mottillo Et al.
    PLoS One  2012;287:25038
  10. Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement.
    Authors: Esposito Et al.
    FASEB J  2011;6:e28668

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PPARy in m1 m2 macrophages
By Anonymous on 09/24/2019
Species: Mouse

Used this produce in mouse macrophages to inhibit ppar gamma at 1um. worked very well


GW 9662 partially inhibits 15d-PGJ2-mediated pp42/44 activation.
By Chintan Koyani on 12/10/2018
Species: Mouse

HL-1 cardiomyocytes were incubated with GW 9662 (2 µM) for 30 min prior to addition of 15 µM 15d-PGJ2 for 30 min. Preincubation of cells with GW 9662 partially abolished activation of p42/44 MAPK, while Tesaglitazar and T 0070907 inhibited the activation completely.


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