Catalog Number: 1508
Chemical Name: 2-Chloro-5-nitro-N-phenylbenzamide
Biological Activity
Selective PPARγ antagonist (IC50 values are 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively). Blocks the inhibition of osteoclast formation induced by IL-4 in the low micromolar range (1-2 μM), therefore is more potent than BADGE (Cat. No. 1326). Anticancer, inhibits growth of human mammary tumor cell lines.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in ethanol with gentle warming and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor γ1.
    Bendixen et al.
    Proc.Natl.Acad.Sci.U.S.A., 2001;98:2443
  2. Functional consequences of cysteine modification in the ligand binding sites of peroxisone proliferator activated receptors by GW9662.
    Leesnitzer et al.
    Biochemistry, 2002;41:6640
  3. GW9662, a potent antaognist of PPARγ, inhibits growth of breast tumour cells and promotes the anticancer effects of the PPARγ agonist rosiglitazone, independently of PPARγ activation.
    Seargent et al.
    Br.J.Pharmacol., 2004;143:933
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