Chemical Name: 2-Chloro-5-nitro-N-phenylbenzamide
Biological ActivityGW 9662 is a selective irreversible PPARγ antagonist (IC50 values are 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively). Blocks the inhibition of osteoclast formation induced by IL-4 in the low micromolar range (1-2 μM), therefore is more potent than BADGE (Cat. No. 1326). Anticancer, inhibits growth of human mammary tumor cell lines.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor γ1.
Bendixen et al.
Functional consequences of cysteine modification in the ligand binding sites of peroxisone proliferator activated receptors by GW9662.
Leesnitzer et al.
GW9662, a potent antaognist of PPARγ, inhibits growth of breast tumour cells and promotes the anticancer effects of the PPARγ agonist rosiglitazone, independently of PPARγ activation.
Seargent et al.
Citations for GW 9662
The citations listed below are publications that use Tocris products. Selected citations for GW 9662 include:
13 Citations: Showing 1 - 10
Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties.
Authors: Smith Et al.
Psychopharmacology (Berl) 2019;
Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis.
Authors: Guo Et al.
Nat Med 2018;24:360
Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell Formation.
Authors: Kotla and Rao
J Biol Chem 2015;290:30306
Additive Renoprotection by pioglit. and fenofi. against Inflammatory, Oxidative and Apoptotic Manifestations of cisp. Nephrotoxicity: Modulation by PPARs.
Authors: Helmy Et al.
PLoS One 2015;10:e0142303
Mechanisms of Nifedipine-Downregulated CD40L/sCD40L Signaling in Collagen Stimulated Human Platelets.
Authors: Chen Et al.
PLoS One 2015;10:e0127054
Antiplatelet activity of nifed. is mediated by inhibition of NF-κB activation caused by enhancement of PPAR-β/-γ activity.
Authors: Shih Et al.
Br J Pharmacol 2014;171:1490
Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α.
Authors: Scuderi Et al.
Arterioscler Thromb Vasc Biol 2012;9:49
Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.
Authors: Ramachandran Et al.
J Biol Chem 2012;287:38028
Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply.
Authors: Mottillo Et al.
PLoS One 2012;287:25038
Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement.
Authors: Esposito Et al.
FASEB J 2011;6:e28668
Antiplatelet actions of STAT and fibrates are mediated by PPARs.
Authors: Ali Et al.
J Neurosci 2009;29:706
Homocysteine up-regulates vascular transmembrane chemokine CXCL16 and induces CXCR6+ lymphocyte recruitment in vitro and in vivo.
Authors: Postea Et al.
J Cell Mol Med 2008;12:1700
Role of nuclear receptor signaling in platelets: antithrombotic effects of PPARβ.
Authors: Ali Et al.
J Neuroinflammation 2006;20:326
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Reviews for GW 9662
Average Rating: 4 (Based on 2 Reviews)
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Used this produce in mouse macrophages to inhibit ppar gamma at 1um. worked very well
HL-1 cardiomyocytes were incubated with GW 9662 (2 µM) for 30 min prior to addition of 15 µM 15d-PGJ2 for 30 min. Preincubation of cells with GW 9662 partially abolished activation of p42/44 MAPK, while Tesaglitazar and T 0070907 inhibited the activation completely.