GYKI 47261 dihydrochloride

Key Product Details

Product Description

GYKI 47261 dihydrochloride is a non-competitive AMPA receptor antagonist (IC₅₀ = 2.5 μM). Displays broad spectrum anticonvulsive activity and neuroprotective effects in vivo.

Product Specifications for GYKI 47261 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GYKI 47261 dihydrochloride

The following data is based on the product molecular weight 395.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.53 mL	12.64 mL	25.27 mL
5 mM	0.51 mL	2.53 mL	5.05 mL
10 mM	0.25 mL	1.26 mL	2.53 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Bibbiani Combined blockade of AMPA and NMDA glutamate receptors reduces levodopa-induced motor complications in animal models of PD. Exp.Neurol. 2005 PMID: 16203001
• Solyo Research on new AMPA antagonists of 2,3-benzodiazepine type. Pharmazie
• Abraham New non competitive AMPA antagonists. Bioorg.Med.Chem. 2000 PMID: 11003158

Product Documents for GYKI 47261 dihydrochloride