H 151 New
Chemical Name: N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea
Biological ActivitySTING antagonist. Covalently binds STING at Cys91, blocking palmitoylation and preventing assembly of STING clusters. Decreases inflammatory cytokine production in human and mouse cells in vitro. Also blocks CMA (Cat. No. 6677) -induced increases in levels of inflammatory cytokines in mice, and alleviates systemic inflammation in a mouse model of autoinflammatory disease.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Targeting STING with covalent small-molecule inhibitors.
Haag et al.
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