Chemical Name: 2,3-Dihydro-2-[3-(4-nitrophenoxy)phenyl]-1,3-dioxo-1H-isoindole-5-carboxylic acid
Biological ActivityH2L 5765834 is an antagonist of the lysophosphatidic acid receptors LPA1, LPA5 and LPA3 (IC50 values are 94, 463 and 752 nM respectively). Exhibits no effect at LPA2 or LPA4 receptors.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Complete Your Experiment
Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation.
Williams et al.
2D binary QSAR modeling of LPA3 receptor antagonism.
Fells et al.
J.Mol.Graph Model., 2010;28:828
Aiming drug discovery at lysophosphatidic acid targets.
Citation for H2L 5765834
The citations listed below are publications that use Tocris products. Selected citations for H2L 5765834 include:
1 Citation: Showing 1 - 1
Lysophosphatidic acid-induced itch is mediated by signalling of LPA5 receptor, phospholipase D and TRPA1/TRPV1.
Authors: Kittaka Et al.
J Physiol 2017;595:2681
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for H2L 5765834
There are currently no reviews for this product. Be the first to review H2L 5765834 and earn rewards!
Have you used H2L 5765834?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image