Catalog Number: 4870
Chemical Name: 2,3-Dihydro-2-[3-(4-nitrophenoxy)phenyl]-1,3-dioxo-1H-isoindole-5-carboxylic acid
Biological Activity
Antagonist of the lysophosphatidic acid receptors LPA1, LPA5 and LPA3 (IC50 values are 94, 463 and 752 nM respectively). Exhibits no effect at LPA2 or LPA4 receptors.
Technical Data
  • M.Wt:
    404.33
  • Formula:
    C21H12N2O7
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    420841-84-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation.
    Williams et al.
    J.Biol.Chem., 2009;284:17304
  2. 2D binary QSAR modeling of LPA3 receptor antagonism.
    Fells et al.
    J.Mol.Graph Model., 2010;28:828
  3. Aiming drug discovery at lysophosphatidic acid targets.
    Tigyi
    Br.J.Pharmacol., 2010;161:241

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