Chemical Name: 2,3-Dihydro-2-[3-(4-nitrophenoxy)phenyl]-1,3-dioxo-1H-isoindole-5-carboxylic acid
Biological ActivityAntagonist of the lysophosphatidic acid receptors LPA1, LPA5 and LPA3 (IC50 values are 94, 463 and 752 nM respectively). Exhibits no effect at LPA2 or LPA4 receptors.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation.
Williams et al.
2D binary QSAR modeling of LPA3 receptor antagonism.
Fells et al.
J.Mol.Graph Model., 2010;28:828
Aiming drug discovery at lysophosphatidic acid targets.
Citation for H2L 5765834
The citations listed below are publications that use Tocris products. Selected citations for H2L 5765834 include:
1 Citation: Showing 1 - 1
Lysophosphatidic acid-induced itch is mediated by signalling of LPA5 receptor, phospholipase D and TRPA1/TRPV1.
Authors: Kittaka Et al.
J Physiol 2017;595:2681
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MG-63 cells were treated with LPA (10 µM) alone or in combination with C3 (20 µM), PTX (Pertussis Toxin, 400 ng/ml) or H2L 5765834 (20 µM) for 3 h to follow COX-2 expression using Western blot. H2L inhibited COX-2 expression induced by LPA.