H2L 5765834

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4870/10
4870/50
H2L 5765834 | CAS No. 420841-84-5 | Lysophosphatidic Acid (LPA) Receptor Antagonists
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Description: LPA1,3,5 antagonist

Chemical Name: 2,3-Dihydro-2-[3-(4-nitrophenoxy)phenyl]-1,3-dioxo-1H-isoindole-5-carboxylic acid

Purity: ≥99%

Product Details
Citations (1)
Supplemental Products
Reviews (1)

Biological Activity

Antagonist of the lysophosphatidic acid receptors LPA1, LPA5 and LPA3 (IC50 values are 94, 463 and 752 nM respectively). Exhibits no effect at LPA2 or LPA4 receptors.

Technical Data

M.Wt:
404.33
Formula:
C21H12N2O7
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
420841-84-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for H2L 5765834

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H2L 5765834 inhibits LPA induced COX-2 expression in osteosarcoma cells
By Christopher Trummer on 10/23/2018
Species: Human

MG-63 cells were treated with LPA (10 µM) alone or in combination with C3 (20 µM), PTX (Pertussis Toxin, 400 ng/ml) or H2L 5765834 (20 µM) for 3 h to follow COX-2 expression using Western blot. H2L inhibited COX-2 expression induced by LPA.


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