Catalog # Availability Size / Price Qty
Harmine | CAS No. 442-51-3 | DYRK Inhibitors
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Description: Potent and selective DYRK1A inhibitor

Chemical Name: 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole

Purity: ≥98%

Product Details
Citations (2)

Biological Activity

Harmine is a potent and selective inhibitor of DYRK1A (IC50 values are 80, 800 and 900 nM for DYRK1A, DYRK3 and DYRK2 respectively). Inhibits DYRK1A-mediated tau phosphorylation and regulates PPARγ expression. Harmine also induces pancreatic β cell proliferation and exhibits antidiabetic activity. Orally bioavailable. Harmine has high affinity (Kd = 100 nM) for the yjdF aptamer. The riboswitch function of yjdF motif RNAs is activated by Harmine and leads to robust reporter gene expressions in B. subtilis.

Technical Data

Soluble to 100 mM in DMSO and to 5 mM in ethanol with gentle warming
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Harmine

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