Catalog Number: 0535
Alternate Names: BE 2254
Chemical Name: 2-{[β-(4-Hydroxyphenyl)ethyl]aminomethyl}-1-tetralone hydrochloride
Biological Activity
Very selective α1-adrenoceptor antagonist, precursor of the 3-[125I]-derivative.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Mechanisms of pressor effect of 5,6-dihydroxytryptamine in pithed rats.
    Baumgarten et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1972;274:375
  2. Interaction of 2-[β-(4-hydroxyphenyl)ethylaminomethyl]tetralone (BE 2254: 'HEAT') with catecholamine receptors in rat brain membranes.
    Williams et al.
    J.Pharm.Pharmacol., 1978;30:390

The citations listed below are publications that use Tocris products. Selected citations for HEAT hydrochloride include:

Showing Results 1 - 3 of 3

  1. α1-adrenergic receptors positively regulate Toll-like receptor cytokine production from human monocytes and macrophages.
    Authors: Grisanti Et al.
    J Pharmacol Exp Ther
  2. Noradrenergic inputs mediate state dependence of auditory responses in the avian song system.
    Authors: Cardin and Schmidt
    Circ Res
  3. The NK1 receptor mediates both the hyperalgesia and the resistance to morphine in mice lacking noradrenaline.
    Authors: Jasmin Et al.
    Proc Natl Acad Sci U S A
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