Heclin

Catalog # Availability Size / Price Qty
5433/10
5433/50

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Heclin | CAS No. 890605-54-6 | Ubiquitin Ligase (E3) Inhibitors
1 Image
Description: HECT E3 ubiquitin ligase inhibitor

Chemical Name: N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Heclin is a HECT E3 ubiquitin ligase inhibitor; inhibits Nedd4, Smurf2 and WWP1 (IC50 values are 6.3, 6.8 and 6.9 μM respectively). Selective for HECT-mediated over RING-mediated ubiquitination.

Technical Data

M.Wt:
283.32
Formula:
C17H17NO3
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
890605-54-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Peptide and small molecule inhibitors of HECT-type ubiquitin ligases.
    Mund et al.
    Proc.Natl.Acad.Sci.U.S.A., 2014;111:16736

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Citation for Heclin

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