HECT E3 ubiquitin ligase inhibitor; inhibits Nedd4, Smurf2 and WWP1 (IC50
values are 6.3, 6.8 and 6.9 μ
M respectively). Selective for HECT-mediated over RING-mediated ubiquitination.
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All Tocris products are intended for laboratory research use only.
Peptide and small molecule inhibitors of HECT-type ubiquitin ligases.
Mund et al.