Histamine dihydrochloride
Chemical Name: 2-(4-Imidazolyl)ethylamine dihydrochloride
Biological Activity
Endogenous agonist at histamine receptors (H1-4). Released from mast cells and basophils and exhibits inflammatory, vasodilatory and bronchoconstrictory activity. Stimulates gastric acid secretion and acts as a neurotransmitter in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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International union of pharmacology. XIII. Classification of histamine receptors.
Hill et al.
Pharmacol.Rev., 1997;49:253 -
The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines.
Thurmond et al.
Nat.Rev.Drug Discov., 2008;7:41 -
Histamine and histamine intolerance.
Maintz and Novak
Am.J.Clin.Nutr., 2007;85:1185
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Citations for Histamine dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Histamine dihydrochloride include:
4 Citations: Showing 1 - 4
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Bone Marrow Myeloid Cells Regulate Myeloid-Biased Hematopoietic Stem Cells via a Histamine-Dependent Feedback Loop.
Authors: Chen Et al.
Cell Stem Cell 2017;21:747
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Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
Authors: Gerhold Et al.
J Neurosci 2015;35:9580
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Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression.
Authors: Femenia Et al.
Int J Neuropsychopharmacol 2015;18
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Gαq/11-mediated intracellular calcium responses to retrograde flow in endothelial cells.
Authors: Melchior and Frangos
Acta Pharmacol Sin 2012;303:C467
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EA.hy926 cells were loaded with cytosolic Ca2+ sensitive dye, Fura-2AM in normal tyrode solution for 40 min and excited alternately at 340 and 380 nm and fluorescence was captured at 510 nm. ER Ca2+ store was depleted with 100 µM histamine in 0.1 mM EGTA-tyrode solution, resulting in transient cytosolic Ca2+ peak.
