Catalog Number: 3545
Chemical Name: 2-(4-Imidazolyl)ethylamine dihydrochloride
Biological Activity
Endogenous agonist at histamine receptors (H1-4). Released from mast cells and basophils and exhibits inflammatory, vasodilatory and bronchoconstrictory activity. Stimulates gastric acid secretion and acts as a neurotransmitter in vivo.
Technical Data
  • M.Wt:
    184.07
  • Formula:
    C5H9N3.2HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Storage:
    Desiccate at RT
  • CAS No:
    56-92-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. International union of pharmacology. XIII. Classification of histamine receptors.
    Hill et al.
    Pharmacol.Rev., 1997;49:253
  2. The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines.
    Thurmond et al.
    Nat.Rev.Drug Discov., 2008;7:41
  3. Histamine and histamine intolerance.
    Maintz and Novak
    Am.J.Clin.Nutr., 2007;85:1185
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Histamine dihydrochloride include:

3 Citations: Showing 1 - 3
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  1. Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
    Authors: Gerhold Et al.
    J Neurosci 2015;35:9580
  2. Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression.
    Authors: Femenia Et al.
    Int J Neuropsychopharmacol 2015;18
  3. Gαq/11-mediated intracellular calcium responses to retrograde flow in endothelial cells.
    Authors: Melchior and Frangos
    Acta Pharmacol Sin 2012;303:C467

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