HLI 373

Key Product Details

Product Description

HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3). Blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53; activates p53-dependent transcription. Induces apoptosis in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS.

Product Specifications for HLI 373

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for HLI 373

The following data is based on the product molecular weight 414.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.41 mL	12.07 mL	24.14 mL
5 mM	0.48 mL	2.41 mL	4.83 mL
10 mM	0.24 mL	1.21 mL	2.41 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Yang Targeting the ubiquitin-proteasome system for cancer therapy. Cancer Sci. 2009 PMID: 19037995
• Kitagaki Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2. Mol.Cancer Ther. 2008 PMID: 18723490

Product Documents for HLI 373