HLI 373

Catalog # Availability Size / Price Qty
3503/10
3503/50
HLI 373 | CAS No. 1782531-99-0 | p53 Activators
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Description: Hdm2 inhibitor; activates p53-dependent transcription

Chemical Name: 5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride

Purity: ≥99%

Product Details
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Biological Activity

Inhibitor of Hdm2 ubiquitin ligase (E3). Blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53; activates p53-dependent transcription. Induces apoptosis in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS.

Technical Data

M.Wt:
414.33
Formula:
C18H23N5O2.2HCl
Solubility:
Soluble to 100 mM in water and to 10 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
1782531-99-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2.
    Kitagaki et al.
    Mol.Cancer Ther., 2008;7:2445
  2. Targeting the ubiquitin-proteasome system for cancer therapy.
    Yang et al.
    Cancer Sci., 2009;100:24

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