Chemical Name: 5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride
Biological ActivityInhibitor of Hdm2 ubiquitin ligase (E3). Blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53; activates p53-dependent transcription. Induces apoptosis in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2.
Kitagaki et al.
Mol.Cancer Ther., 2008;7:2445
Targeting the ubiquitin-proteasome system for cancer therapy.
Yang et al.
Cancer Sci., 2009;100:24
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