HMR 1556

Tocris Bioscience | Catalog # 5011

Potent and selective Iks channel blocker
Tocris Bioscience

Key Product Details

Description

Potent and selective Iks channel blocker
View all Voltage-gated Potassium Channel Blockers »

Product Description

HMR 1556 is a potent and selective Iks channel blocker (IC50 values are 10.5 and 34 nM in canine and guinea pig ventricular myocytes respectively). Selectively inhibits IKs currents over IKr, IKI, Ito and L-type Ca2+ channel currents. Also has little or no effect on Kv11.1 Kv1.5, Kv1.3, Kir2.1 and HCN2 channel currents. Potentiates E-4031-induced arrhythmias in vivo.

Product Specifications for HMR 1556

Molecular Weight

411.44

Formula

C17H24F3NO5S

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide

CAS Number

223749-46-0

PubChem ID

9887834

InChI Key

SRZRLJWUQFIZRH-LSDHHAIUSA-N

SMILES

CC2(C)[C@H](O)[C@@H](N(S(C)(=O)=O)C)C1=CC(OCCCC(F)(F)F)=CC=C1O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.14 100

Preparing Stock Solutions for HMR 1556

The following data is based on the product molecular weight 411.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.15 mL 24.30 mL
5 mM 0.49 mL 2.43 mL 4.86 mL
10 mM 0.24 mL 1.22 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 35 publications citing the usage of this product.

Product Documents for HMR 1556

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for HMR 1556

For research use only

Customer Reviews for HMR 1556 (1)

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  • HMR 1556 shortens cardiac action potential duration
    Name: Anonymous
    Species: Guinea Pig
    Assay Type: In Vitro
    Cell Line/Tissue: Cardiomyocytes
    Verified Customer | Posted 05/16/2019
    A representative action potential of a guinea pig cardiomyocyte before and after superfusion with 500 nM HMR 1556 for 5 min and stimulated at a frequency of 1 Hz in a whole cell patch clamp model. HMR 1556 significantly shortened action potential duration of guinea pig ventricular cardiomyocytes.
    HMR 1556 5011

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