Catalog Number: 1416
Chemical Name: Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
Biological Activity
Inhibitor of protein synthesis. Blocks elongation phase of translation by binding to the 60-S ribosome subunit. Antileukemic.
Technical Data
  • M.Wt:
    545.63
  • Formula:
    C29H39NO9
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    26833-87-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation, mitochondrial cytochrome c release and caspase activation.
    Cai et al.
    Leukemia, 2001;15:567
  2. Inhibition of translation in eukaryotic systems by harringtonine.
    Fresno et al.
    Eur.J.Biochem., 1977;72:323
  3. Homoharringtonine: an effective new natural product in cancer chemotherapy.
    Zhou et al.
    Bull.Cancer, 1995;82:987
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Homoharringtonine include:

2 Citations: Showing 1 - 2
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  1. Splicing promotes the nuclear export of β-globin mRNA by overcoming nuclear retention elements.
    Authors: Akef Et al.
    Cell J 2015;21:1908
  2. Identification of repurposed small molecule drugs for chordoma therapy.
    Authors: Xia Et al.
    Cancer Biol Ther 2013;14:638

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