Chemical Name: Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
Biological ActivityHomoharringtonine is an inhibitor of protein synthesis. Blocks elongation phase of translation by binding to the 60-S ribosome subunit. Antileukemic. Inhibits SARS-CoV-2 infection in vitro (IC50 = 2.55 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation, mitochondrial cytochrome c release and caspase activation.
Cai et al.
Inhibition of translation in eukaryotic systems by harringtonine.
Fresno et al.
Homoharringtonine: an effective new natural product in cancer chemotherapy.
Zhou et al.
Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro.
Choy et al.
Antiviral Res., 2020;178
Citations for Homoharringtonine
The citations listed below are publications that use Tocris products. Selected citations for Homoharringtonine include:
3 Citations: Showing 1 - 3
AMPK activation regulates P-body dynamics in mouse sensory neurons in vitro and in vivo.
Authors: Paige Et al.
Neurobiol Pain 2019;5
Splicing promotes the nuclear export of β-globin mRNA by overcoming nuclear retention elements.
Authors: Akef Et al.
Cell J 2015;21:1908
Identification of repurposed small molecule drugs for chordoma therapy.
Authors: Xia Et al.
Cancer Biol Ther 2013;14:638
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Homoharringtonine
There are currently no reviews for this product. Be the first to review Homoharringtonine and earn rewards!
Have you used Homoharringtonine?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image