Orally active and specific inhibitor of human hematopoietic prostaglandin D synthase (H-PGDS) (IC50
= 6 μ
M). Antiallergic and anti-inflammatory; displays antiasthmatic activity and potent antihistaminic properties in vivo
Soluble to 25 mM in DMSO
Store at RT
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All Tocris products are intended for laboratory research use only.
Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase.
Aritake et al.
Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antihistaminic effects.
Matsushita et al.
Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher.
Mohri et al.