Catalog Number: 3530
Chemical Name: 4-(Diphenylmethoxy)-1-(3-2H-tetrazol-5-yl)propyl]-piperidine
Biological Activity
Orally active and specific inhibitor of human hematopoietic prostaglandin D synthase (H-PGDS) (IC50 = 6 μM). Antiallergic and anti-inflammatory; displays antiasthmatic activity and potent antihistaminic properties in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase.
    Aritake et al.
    J.Biol.Chem., 2006;281:15277
  2. Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antihistaminic effects.
    Matsushita et al.
    Jpn.J.Pharmacol., 1998;78:11
  3. Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher.
    Mohri et al.
    J.Neurosci., 2006;26:4383
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