Potent and selective melanocortin MC4
receptor antagonist (Ki
values are 3.16, 108, 54.4 and 694 nM for cloned human MC4
receptors respectively). Increases food intake in rats and nociception in mice following central administration in vivo
. Also inhibits IL-1β
-induced Fos expression in the paraventricular hypothalamus.
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All Tocris products are intended for laboratory research use only.
Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test.
Bellasio et al.
Discovery of novel melanocortin4 receptor selective MSH analogues.
Schioth et al.
Central blockade of melanocortin receptors attenuates the metabolic and locomotor responses to peripheral interleukin-1β administration.
Whitaker and Reye
The citations listed below are publications that use Tocris products. Selected citations for HS 014 include:
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