HS 024

Tocris Bioscience | Catalog # 1832

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Citations (12)

Product Documents

Highly potent MC4 receptor antagonist

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Highly potent MC4 receptor antagonist

View all Melanocortin Receptor Antagonists »

Product Description

HS 024 is a highly potent melanocortin MC₄ receptor antagonist (K_i values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC₄, MC₁, MC₃ and MC₅ receptors respectively). Increases food intake, and blocks α-MSH- and MTII-induced hypotension and bradycardia in rats, following central administration in vivo.

Product Specifications for HS 024

Molecular Weight

1266.50

Formula

C₅₈H₇₉N₁₉O₁₀S₂

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

212370-59-7

PubChem ID

25081552

InChI Key

PUOCNCOPVAOMDE-LQXMKOPKSA-N

SMILES

CCCC[C@@H]1NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O)NC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 0.5mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

Jonsson Food conversion is transiently affected during 4-week chronic administration of melanocortin agonist and antagonist in rats. J.Endocrinol. 2002 PMID: 12065241
Kask Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology 1998 PMID: 9832440
Jonsson Melanocortin receptor agonist transiently increases oxygen consumption in rats. Neuroreport 2001 PMID: 11726778

Product Documents for HS 024

Certificate of Analysis

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Download SDS

Product Specific Notices for HS 024

For research use only

Related Research Areas

Metabolic Peptide Hormones and Regulators

Nutrition and Appetite

Citations for HS 024

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