HS 024

  ( 1 citations )    
Product Datasheet
Catalog Number:1832
Chemical Name:
Product Details
Citations (1)
Supplemental Products
Reviews
Biological Activity
Highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks α-MSH- and MTII-induced hypotension and bradycardia in rats, following central administration in vivo.
Technical Data
  • M.Wt:
    1266.5
  • Formula:
    C58H79N19O10S2
  • Sequence:
    CXRHXRWGC

    (Modifications: Cys-1 = N-terminal Ac, X-2 = Nle, X-5 = Nal, Cys-9 = C-terminal amide, Disulfide bridge between 1 - 9)

  • Solubility:
    Soluble to 0.50 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    212370-59-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for HS 024 include:

1 Citations: Showing 1 - 1

  1. Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5.
    Authors: Simamura Et al.
    J Neurochem  2015;10:e0123232

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