Catalog Number: 1832
Biological Activity
Highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks α-MSH- and MTII-induced hypotension and bradycardia in rats, following central administration in vivo.
Technical Data
  • M.Wt:
    1266.5
  • Formula:
    C58H79N19O10S2
  • Sequence:
    CXRHXRWGC

    (Modifications: Cys-1 = N-terminal Ac, X-2 = Nle, X-5 = Nal, Cys-9 = C-terminal amide, Disulfide bridge between 1 - 9)

  • Solubility:
    Soluble to 0.50 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    212370-59-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Melanocortin receptor agonist transiently increases oxygen consumption in rats.
    Jonsson et al.
    Neuroreport, 2001;12:3703
  2. Food conversion is transiently affected during 4-week chronic administration of melanocortin agonist and antagonist in rats.
    Jonsson et al.
    J.Endocrinol., 2002;173:517
  3. Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo.
    Kask et al.
    Endocrinology, 1998;139:5006
Citations:

The citations listed below are publications that use Tocris products. Selected citations for HS 024 include:

1 Citations: Showing 1 - 1

  1. Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5.
    Authors: Simamura Et al.
    J Neurochem 2015;10:e0123232

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