Chemical Name: 6-[2-(4-Imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl)heptanecarboxamide dimaleate
Biological ActivityHTMT dimaleate is a H1 and H2 receptor agonist. 4x104 times more active than histamine in H2-mediated effects in natural suppressor cells. Increases intracellular Ca2+ and IP3 in lymphocytes through a binding site other than H1, H2 or H3.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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The effects of derivatives of histamine on natural suppressor cells.
Khan et al.
Congener derivatives and conjugates of histamine: synthesis and tissue receptor selectivity of the derivatives.
Khan et al.
Histamine, histamine receptors and their role in immunomodulation: An updated systematic review.
Shahid et al.
Open Immunol.J., 2009;2:9
Citations for HTMT dimaleate
The citations listed below are publications that use Tocris products. Selected citations for HTMT dimaleate include:
2 Citations: Showing 1 - 2
TRPV1-lineage neurons are required for thermal sensation.
Authors: Mishra Et al.
Br J Ophthalmol 2011;30:582
The Influence of histamine H1-receptor on liver functions in immunized rabbits.
Authors: Tripathi Et al.
EMBO J 2011;18:411
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