Catalog Number: 0646
Alternate Names: Histamine trifluoromethyl toluidide
Chemical Name: 6-[2-(4-Imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl)heptanecarboxamide dimaleate
Biological Activity
H1 and H2 receptor agonist. 4x104 times more active than histamine in H2-mediated effects in natural suppressor cells. Increases intracellular Ca2+ and IP3 in lymphocytes through a binding site other than H1, H2 or H3.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Congener derivatives and conjugates of histamine: synthesis and tissue receptor selectivity of the derivatives.
    Khan et al.
    J.Med.Chem., 1987;30:2115
  2. The effects of derivatives of histamine on natural suppressor cells.
    Khan et al.
    J.Immunol., 1986;137:308
  3. Histamine, histamine receptors and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9

The citations listed below are publications that use Tocris products. Selected citations for HTMT dimaleate include:

Showing Results 1 - 2 of 2

  1. TRPV1-lineage neurons are required for thermal sensation.
    Authors: Mishra Et al.
    Br J Ophthalmol
  2. The Influence of histamine H1-receptor on liver functions in immunized rabbits.
    Authors: Tripathi Et al.
    EMBO J
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