Chemical Name: (1S,4S,5S)-4-[4-(1,1-Dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-methanol
Biological ActivityHU 308 is a potent and selective CB2 receptor agonist (Ki values are 22.7 nM and > 10 μM for CB2 and CB1 receptors respectively, EC50 = 5.57 nM). Displays antiallodynic activity in the rat hindpaw incision model of postoperative pain. Also neuroprotective and improves motor performance in a mouse model of Huntington's Disease.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity.
Palazuelos et al.
Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain.
LaBuda et al.
HU-308: a specific agonist for CB2, a peripheral cannabinoid receptor.
Hanus et al.
Citations for HU 308
The citations listed below are publications that use Tocris products. Selected citations for HU 308 include:
7 Citations: Showing 1 - 7
Altered Swimming Behaviors in Zebrafish Larvae Lacking Cannabinoid Receptor 2.
Authors: Acevedo-Canabal Et al.
Cannabis Cannabinoid Res 2019;4:88
Antiallodynic Effects of Cannabinoid Receptor 2 (CB2R) Agonists on Retrovirus Infection-Induced Neuropathic Pain.
Authors: Sheng Et al.
Pain Res Manag 2019;2019:1260353
Activation of Cannabinoid Receptor 2 Ameliorates DSS-Induced Colitis through Inhibiting NLRP3 Inflammasome in Macrophages
Authors: Ke Et al.
PLoS One 2016;11:e0155076
Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist.
Authors: Presley Et al.
Brain Res 2015;3:e00159
Ligand-based virtual screening identifies a family of selective cannabinoid receptor 2 agonists.
Authors: Gianella-Borradori Et al.
Bioorg Med Chem 2015;23:241
Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis.
Authors: Sardinha Et al.
Pharmacol Res Perspect 2014;2014:978678
Prospects for cannabinoid therapies in viral encephalitis.
Authors: Solbrig Et al.
Proc Natl Acad Sci U S A 2013;1537:273
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