HU 308

  ( 5 citations )    
Product Datasheet
Catalog Number:3088
Chemical Name:4-[4-(1,1-Dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-methanol
Product Details
Citations (5)
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Reviews
Biological Activity
Potent and selective CB2 receptor agonist (Ki values are 22.7 nM and > 10 μM for CB2 and CB1 receptors respectively, EC50 = 5.57 nM). Displays antiallodynic activity in the rat hindpaw incision model of postoperative pain. Also neuroprotective and improves motor performance in a mouse model of Huntington's Disease.
Technical Data
  • M.Wt:
    414.62
  • Formula:
    C27H42O3
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    256934-39-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from Hebrew University of Jerusalem
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for HU 308 include:

5 Citations: Showing 1 - 5
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  1. Activation of Cannabinoid Receptor 2 Ameliorates DSS-Induced Colitis through Inhibiting NLRP3 Inflammasome in Macrophages
    Authors: Ke Et al.
    PLoS One  2016;11:e0155076
  2. Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist.
    Authors: Presley Et al.
    Brain Res  2015;3:e00159
  3. Ligand-based virtual screening identifies a family of selective cannabinoid receptor 2 agonists.
    Authors: Gianella-Borradori Et al.
    Bioorg Med Chem  2015;23:241
  4. Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis.
    Authors: Sardinha Et al.
    Pharmacol Res Perspect  2014;2014:978678
  5. Prospects for cannabinoid therapies in viral encephalitis.
    Authors: Solbrig Et al.
    Proc Natl Acad Sci U S A  2013;1537:273

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