Human 5-HT1B Antibody

Catalog # Availability Size / Price Qty
Product Details
Supplemental Products

Human 5-HT1B Antibody Summary

Species Reactivity
Detects human 5HT1B.
Monoclonal Mouse IgG1 Clone # 499325
Protein A or G purified from hybridoma culture supernatant
NS0 mouse myeloma cell line transfected with human 5HT1B
Accession # P28222
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
8-25 µg/mL
Immersion fixed paraffin-embedded sections of human brain (cortex and glia)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: 5-HT1B

5HT1B is a 7TM receptor for serotonin and is expressed on striatal neurons and Purkinje cells in the cerebellum. 5HT1B ligation inhibits glycinergic signaling, appetite, circadian rhythm light responsiveness, and trigeminal-mediated nociception. It is an important pharmacologic target in the treatment of migrane headaches. Human 5HT1B shares 92% aa sequence identity with mouse and rat 5HT1B.

Long Name
5-Hydroxytryptamine Receptor 1B
Entrez Gene IDs
3351 (Human); 15551 (Mouse); 25075 (Rat)
Alternate Names
5HT1B; 5-HT1B; 5-HT1B5-HT-1B; 5HT1DB; 5-HT1DB; 5-hydroxytryptamine (serotonin) receptor 1B; HTR1B; HTR1D2; HTR1D2,5-hydroxytryptamine receptor 1B; HTR1DB; S12; S125-HT-1D-beta; Serotonin 1D beta receptor; Serotonin receptor 1B

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Isotype Controls

Reconstitution Buffers

Secondary Antibodies

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