Human ACE/CD143 (NP_000780.1) VersaClone cDNA

Name: Human ACE/CD143 (NP_000780.1) VersaClone cDNA
Brand: R&D Systems
SKU: RDC3482
Price: 1079 USD
Availability: InStock

R&D Systems | Catalog # RDC3482

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Product Documents

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Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species

Human

Accession Number

NP_000780.1

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: ACE/CD143

ACE and ACE-2, two cell surface proteases, are important regulators of the renin-angiotensin system (RAS), which plays a key role in maintaining blood pressure homeostasis and fluid salt balance in mammals. Because of its location and specificity, ACE plays additional roles in immunity, reproduction and neuropeptide regulation. ACE exists in two isoforms. Somatic ACE comprises two highly similar protease domains whereas germinal ACE comprises a single protease domain. ACE-2 consists of a single protease domain and is an essential regulator of heart and lung function. It is also a cellular receptor for the Spike protein of SARS coronavirus that causes severe acute respiratory syndrome.