Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Western Blot

Cited:

Western Blot, Flow Cytometry

Label

Biotin

Antibody Source

Polyclonal Goat IgG
View all Activin RIIB Primary Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Activin RIIB
Ser19-Thr134
Accession # CAA54671

Specificity

Detects human Activin RIIB in Western blots. In this format, less than 1% cross-reactivity with recombinant human (rh) Activin RIA, rhActivin RIB, and rhActivin RIIA is observed.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for Human Activin RIIB Antibody [Biotin]

Application
Recommended Usage

Western Blot

0.1 µg/mL
Sample: Recombinant Human Activin RIIB Fc Chimera (Catalog # 339-RB)

Reviewed Applications

Read 1 review rated 5 using BAF339 in the following applications:

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Activin RIIB

Activin isoforms and other members of the TGF-beta  superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction. Seven type I and five type II receptors, including the two type I and the two type II activin receptors, designated ActR-I(A), ActR-IB, ActR-II(A) and ActR-IIB, have been cloned from mammals. Through alternative mRNA splicing, multiple ActR-IIB isoforms can also be generated, adding to the complexity of the activin receptor system. Different activin isoforms bind with different high-affinities to the various type II isoforms. Type I activin receptors do not bind directly to activin, but will associate with the type II receptor-activin complex and initiate signal transduction. Besides the activin isoforms, ActR-II will also bind inhibin, BMP-2 and BMP-7 with lower affinities. ActR-I can also bind and form signaling complexes with the BMP-2/7-bound BMPR-II. Activin type II receptors are highly conserved. Human, mouse and rat type II activin receptors share greater than 98% amino acid sequence homology.

References

  1. Attisano, L. et al. (1996) Mol. and Cell Biol. 16:1066.
  2. Woodruff, T.K. (1998) Biochem. Pharmacology 55:953.

Long Name

Activin Receptor IIB

Alternate Names

ActivinRIIB, ACVR2B

Entrez Gene IDs

93 (Human); 11481 (Mouse)

Gene Symbol

ACVR2B

UniProt

CAA54671

Additional Activin RIIB Products

Product Documents for Human Activin RIIB Antibody [Biotin]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human Activin RIIB Antibody [Biotin]

For research use only

Related Research Areas

Activin Family

Citations for Human Activin RIIB Antibody [Biotin]

Customer Reviews for Human Activin RIIB Antibody [Biotin] (1)

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  • Human Activin RIIB Biotinylated Antibody
    Name: Anonymous
    Application: ELISA
    Sample Tested: Human recombinant test antibody
    Species: recombinant protein and Mouse
    Verified Customer | Posted 04/07/2020
    Human Activin RIIB Antibody [Biotin] BAF339

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