ADAM22 (a disintegrin and metalloprotease 22; also MDC2) is an 85‑90 kDa member of the M12B peptidase family of enzymes. It is expressed on both neurons and astrocytes in cranial regions of the CNS. The human ADAM22 proprecursor is an 881 amino acid (aa) type I transmembrane protein. It contains a 197 aa cleavable proregion (aa 26‑222) and a 512 aa extracellular domain (ECD) (aa 223‑736). The ECD contains a nonfunctional metalloprotease domain (aa 239‑438), an integrin‑binding disintegrin region (aa 444‑531) and a Cys‑rich domain (aa 532‑678). Multiple splice variants exist, two of which may involve the ECD. Both show premature truncations. One has a 10 aa substitution for aa 234‑906, while a second shows an 11 aa substitution for aa 332‑906. Over aa 26‑528, human ADAM22 is 90% aa identical to mouse ADAM22.
Human ADAM22 Alexa Fluor™ Plus 405‑conjugated Antibody
R&D Systems | Catalog # AF4908AFP405
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Specificity
Clonality
Host
Isotype
Applications for Human ADAM22 Alexa Fluor™ Plus 405‑conjugated Antibody
Immunoprecipitation
Western Blot
Formulation, Preparation, and Storage
Formulation
Shipping
Stability & Storage
Background: ADAM22
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Alternate Names
Gene Symbol
UniProt
Additional ADAM22 Products
Product Documents for Human ADAM22 Alexa Fluor™ Plus 405‑conjugated Antibody
Certificate of Analysis
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Product Specific Notices for Human ADAM22 Alexa Fluor™ Plus 405‑conjugated Antibody
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
- Cellular Response to Hypoxia Protocols
- Immunoprecipitation Protocol
- R&D Systems Quality Control Western Blot Protocol
- Troubleshooting Guide: Western Blot Figures
- Western Blot Conditions
- Western Blot Protocol
- Western Blot Protocol for Cell Lysates
- Western Blot Troubleshooting
- Western Blot Troubleshooting Guide
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