Human ADAM22 Antibody

Catalog # Availability Size / Price Qty
Product Details
Supplemental Products

Human ADAM22 Antibody Summary

Species Reactivity
Detects human ADAM22 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) ADAM8, rhADAM12, and rhADAM33 is observed.
Polyclonal Sheep IgG
Antigen Affinity-purified
Chinese hamster ovary cell line CHO-derived recombinant human ADAM22
Gly26-His528 (Leu78Val)
Accession # Q9P0K1
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
0.1 µg/mL
Recombinant Human ADAM22
25 µg/mL
Conditioned cell culture medium spiked with Recombinant Human ADAM22, see our available Western blot detection antibodies

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: ADAM22

ADAM22 (a disintegrin and metalloprotease 22; also MDC2) is an 85‑90 kDa member of the M12B peptidase family of enzymes. It is expressed on both neurons and astrocytes in cranial regions of the CNS. The human ADAM22 proprecursor is an 881 amino acid (aa) type I transmembrane protein. It contains a 197 aa cleavable proregion (aa 26‑222) and a 512 aa extracellular domain (ECD) (aa 223‑736). The ECD contains a nonfunctional metalloprotease domain (aa 239‑438), an integrin‑binding disintegrin region (aa 444‑531) and a Cys‑rich domain (aa 532‑678). Multiple splice variants exist, two of which may involve the ECD. Both show premature truncations. One has a 10 aa substitution for aa 234‑906, while a second shows an 11 aa substitution for aa 332‑906. Over aa 26‑528, human ADAM22 is 90% aa identical to mouse ADAM22.

Long Name
A Disintegrin and Metalloproteinase Domain 22
Entrez Gene IDs
53616 (Human); 11496 (Mouse); 57033 (Rat)
Alternate Names
ADAM 22; ADAM metallopeptidase domain 22; ADAM22; MDC2; metalloproteinase-disintegrin ADAM22-3; metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2; MGC149832

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