Human ADAM22 Antibody
Human ADAM22 Antibody Summary
Accession # Q9P0K1
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
ADAM22 (a disintegrin and metalloprotease 22; also MDC2) is an 85‑90 kDa member of the M12B peptidase family of enzymes. It is expressed on both neurons and astrocytes in cranial regions of the CNS. The human ADAM22 proprecursor is an 881 amino acid (aa) type I transmembrane protein. It contains a 197 aa cleavable proregion (aa 26‑222) and a 512 aa extracellular domain (ECD) (aa 223‑736). The ECD contains a nonfunctional metalloprotease domain (aa 239‑438), an integrin‑binding disintegrin region (aa 444‑531) and a Cys‑rich domain (aa 532‑678). Multiple splice variants exist, two of which may involve the ECD. Both show premature truncations. One has a 10 aa substitution for aa 234‑906, while a second shows an 11 aa substitution for aa 332‑906. Over aa 26‑528, human ADAM22 is 90% aa identical to mouse ADAM22.
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