Human Airway Trypsin‑like protease (HAT), also known as Transmembrane Protease, Serine 11D (TMPRSSIID), is a type II transmembrane serine protease that is expressed in the cells of the submucosal serous glands of the bronchi and trachea (1‑3). The deduced sequence predicts a short cytoplasmic tail (aa 120), a transmembrane domain (aa 21‑41), and an ectodomain consisting of a SEA domain (aa 44‑164) and a catalytic domain (aa 187‑418). The single‑chain precursor can be converted into a disulfide‑linked two‑chains, one of which corresponds to the catalytic domain. HAT was initially purified from the sputum of patients with chronic airway diseases (1). HAT has been shown to induce PAR‑2 mediated IL‑8 release in psoriasis vulgaris and increase mucin expression in airway epithelial cells (4, 5). The amino acid sequence of human HAT is 99%, 79%, and 67% identical to that of chimpanzee, canine and rat/mouse.
Human Airway Trypsin-like Protease/HAT Alexa Fluor™ Plus 405‑conjugated Antibody
R&D Systems | Catalog # FAB2695AFP405
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Western Blot
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Background: Airway Trypsin-like Protease/HAT
References
- Yasuoka, S. et al. (1997) Am. J. Respir. Cell Mol. Biol. 16:300.
- Yamaoka, K. et al. (1998) J. Biol. Chem. 273:11895.
- Hooper, J.D. et al. (2001) J. Biol. Chem. 276:857.
- Iwakiri, K. et al. (2004) J. Invest. Dermatol. 122:937.
- Chokki, M. et al. (2004) Am. J. Respir. Cell Mol. Biol. 30:470.
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This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
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Protocols
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- Cellular Response to Hypoxia Protocols
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- Troubleshooting Guide: Western Blot Figures
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- Western Blot Protocol
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- Western Blot Troubleshooting
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