Human alpha-1B Adrenergic R/ADRA1B Alexa Fluor® 750-conjugated Antibody

Catalog # Availability Size / Price Qty
IC4730S-100UG
R&D Systems Antibodies
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Human alpha-1B Adrenergic R/ADRA1B Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human ADRA1B. Stains human ADRA1B transfectants but not irrelevant transfectants.
Source
Monoclonal Mouse IgG2b Clone # 471802
Immunogen
NS0 mouse myeloma cell line transfected with human ADRA1B
Met1-Phe520
Accession # P35368
Formulation
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Label
Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration
Sample
Intracellular Staining by Flow Cytometry
0.25-1 µg/106 cells
PC‑3 human prostate cancer cell line fixed with paraformaldehyde and permeabilized with saponin

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: alpha-1B Adrenergic R/ADRA1B

ADRA1B, also known as the alpha -1B-adrenergic receptor, is a 90 kDa 7TM catecholamine receptor with selectivity for epinephrine and norepinephrine. Formation of homooligomers and heterooligomers with ADRA1A enables receptor internalization following ligand binding. ADRA1B functions in diverse settings including vasoconstriction and myocardial contractility, neuronal dopaminergic responses, dendritic cell migration and inflammatory responses, and neuroendocrine regulation of fertility. Human ADRA1B shares 95% amino acid sequence identity with mouse and rat ADRA1B.

Long Name
Alpha-1B Adrenergic Receptor
Entrez Gene IDs
147 (Human); 11548 (Mouse); 24173 (Rat)
Alternate Names
a-1B AdrenergicR; ADRA1; ADRA1B; adrenergic, alpha-1B-, receptor; alpha-1B Adrenergic R; alpha-1B adrenergic receptor; alpha1B AdrenergicR; Alpha-1B adrenoceptor; Alpha-1B adrenoreceptor; alpha-1B-adrenergic receptor; ALPHA1BAR

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