Human Aminopeptidase LRAP/ERAP2 Alexa Fluor® 350-conjugated Antibody

Catalog #: FAB3830U Datasheet / COA / SDS

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FAB3830U-100UG

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Human Aminopeptidase LRAP/ERAP2 Alexa Fluor® 350-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Aminopeptidase LRAP/ERAP2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross‑reactivity with recombinant human PILS is observed.

Source

Monoclonal Mouse IgG1 Clone # 3F5

Purification

Protein A or G purified

Immunogen

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Aminopeptidase LRAP/ERAP2
Accession # Q6P179

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 350 (Excitation= 346 nm, Emission= 442 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Aminopeptidase LRAP/ERAP2

Leukocyte-derived arginine aminopeptidase (LRAP) and endoplasmic reticulum-aminopeptidase 2 (ERAP2) are the two names given to the protein encoded by the LRAP gene (1, 2). Induced by interferon-gamma, LRAP is able to trim various MHC class I antigenic peptide precursors. It belongs to the oxytocinase subfamily of M1 aminopeptidases, which also includes aminopeptidases PILS/ARTS1/ERAP1 and LNPEP/PLAP (1, 3). In addition to antigen presentation, the members of this subfamily are also important in maintenance of pregnancy, memory retention, and blood pressure regulation (3).

Long Name

Leukocyte-derived Arginine Aminopeptidase

Entrez Gene IDs

64167 (Human)

Alternate Names

Aminopeptidase LRAP; EC 3.4.11; EC 3.4.11.3; endoplasmic reticulum aminopeptidase 2; ERAP2; FLJ23633; FLJ23701; FLJ23807; Leukocyte-derived arginine aminopeptidase; LRAPL-RAPEC 3.4.11.-