BLAME (B-lymphocyte activator macrophage expressed), also known as SLAM family member 8, is a type I transmembrane protein that belongs to the CD2 subset of immunoglobulin superfamily cell receptors. CD2 family proteins function as adhesion molecules and modulators of immune responses (1, 2). Mature human BLAME consists of a 211 amino acid (aa) ECD that contains two Ig V-like domains, a 21 aa transmembrane segment, and a 31 aa cytoplasmic tail that lacks recognizable signaling motifs (3). Within the ECD, human BLAME shares 19% - 26% aa sequence identity with human 2B4, CD2, CD2F-10, CD48, CD58, CD84, CD229, CRACC, NTB-A, and SLAM. It shares 79% aa sequence identity with the ECD of mouse BLAME. BLAME is expressed on dendritic cells and IFN-gamma stimulated monocytes. Overexpression of BLAME in bone marrow cells leads to an increase in the peritoneal B1b population of B lymphocytes (3).
Human BLAME/SLAMF8 Alexa Fluor™ Plus 680‑conjugated Antibody
R&D Systems | Catalog # FAB19073AFP680
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Specificity
Clonality
Host
Isotype
Applications for Human BLAME/SLAMF8 Alexa Fluor™ Plus 680‑conjugated Antibody
ELISA Capture (Matched Antibody Pair)
Formulation, Preparation, and Storage
Formulation
Shipping
Stability & Storage
Background: BLAME/SLAMF8
References
- McNerney, M.E. and V. Kumar (2006) Curr. Top. Microbiol. Immunol. 298:91.
- Veillette, A. (2006) Nat. Rev. Immunol. 6:56.
- Kingsbury, G.A. et al. (2001) J. Immunol. 166:5675.
Long Name
Alternate Names
Gene Symbol
UniProt
Additional BLAME/SLAMF8 Products
Product Documents for Human BLAME/SLAMF8 Alexa Fluor™ Plus 680‑conjugated Antibody
Certificate of Analysis
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Product Specific Notices for Human BLAME/SLAMF8 Alexa Fluor™ Plus 680‑conjugated Antibody
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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