Human Caspr1 Alexa Fluor® 488-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Caspr1

CASPR1 (Contactin-ASsociated PRotein-1; also Neurexin-4 and p190) is a 180-195 kDa member of the neurexin family of proteins. It is expressed on both axons and dendrites of neurons, and likely serves the critical function of directing the movement of low MW contactin, AMPA receptors, and Na+ plus K+ channels to appropriate sites on the cell membrane. This indicates participation in key processes such as myelination and excitatory neurotransmission. Mature human CASRP1 is a 1365 amino acid (aa) type I transmembrane protein. It contains a 1264 aa extracellular region (aa 20-1283) plus an 80 aa cytoplasmic domain. The extracellular region is highly modular, possessing one discoidin (carbohydrate-binding) domain (aa 24-158), four laminin G-like domains (aa 203-513, 813-956 and 1088-1250), two EGF-like domains (aa 540-577 and 957-996) and one fibrinogen C-terminal globular regions (aa 576-795). There is one potential alternative start site at Met507. Over aa 20-1280, human CASPR1 shares 94% aa sequence identity with mouse CASPR1.

Product Datasheets

Related Research Areas

• Synaptic Proteins