Human CD-M6PR (NP_002346) VersaClone cDNA

R&D Systems | Catalog # RDC1519

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Key Product Details

Species

Human

Accession Number

NP_002346

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: CD-M6PR

Lysosomal enzymes containing one or two mannose 6-phosphate (man6P) moieties are moved about in the cell by two distinct but interconnected cycles by means of 300 kDa cation independent mannose 6-phospate receptors (CI-MPR). The biosynthetic cycle refers to the MPR transport of newly synthesized lysosomal enzymes from the trans Golgi network to late endosomes or early lysosomes. The endocytic cycle transports extracellular lysosomal enzymes from the plasma membrane via clathrin-coated vesicles to early endosomes. The entire pool of MPRs cycles between these cellular compartments every 3 hours. The steady state distribution of MPR's is predominantly within late endosomes, fewer in the trans Golgi network and ~10 % at cell surface. In addition to its man6P binding activity, the MPR contains a separate binding site for the type II insulin-like growth factor and is capable of binding both man6P and IGF-II simultaneously. An ~240 kDa soluble, truncated form, representing the extracellular domain of the protein, has also been found circulating in serum and is capable of binding both ligands.

Long Name

Cation Dependent Mannose-6-Phosphate Receptor 46 kDa

Alternate Names

CD-MPR, CDM6PR, M6PR, MPR46, MPRD, SMPR

Entrez Gene IDs

4074 (Human); 17113 (Mouse); 312689 (Rat)

Gene Symbol

M6PR

UniProt

NP_002346

Additional CD-M6PR Products

Product Documents for Human CD-M6PR (NP_002346) VersaClone cDNA

Certificate of Analysis

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Product Specific Notices for Human CD-M6PR (NP_002346) VersaClone cDNA

For research use only

Related Research Areas

Lysosomal Enzymes

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