Human CD1d (NP_001757) VersaClone cDNA

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R&D Systems VersaClone cDNA Plasmids
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Human CD1d (NP_001757) VersaClone cDNA Summary


Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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Background: CD1d

CD1d1 is a 48 kDa transmembrane glycoprotein in the CD1 family of glycolipid antigen-presenting MHC-like molecules. Complexes of CD1d1 with beta 2-microglobulin and endogenous glycolipids are constitutively expressed on antigen presenting cells, cortical thymocytes, liver sinusoidal endothelial cells, Kupffer cells, and hepatocytes. CD1d1-presented glycolipids are recognized by canonical NKT cells that utilize an invariant mouse V alpha 14-J alpha 18 chain in their T cell receptor (V alpha 24-J alpha 18 in human). The interaction with glycolipid-loaded CD1d1 is critical for NKT cell development and induces their rapid secretion of both Th1 and Th2 type cytokines. In humans, infection with HSV-1 suppresses NKT cell activation by blocking the intracellular cycling of CD1d1 in antigen presenting cells.

Entrez Gene IDs
912 (Human); 12480 (Mouse); 25109 (Rat)
Alternate Names
antigen-presenting glycoprotein CD1d; CD1A; CD1d antigen; CD1D antigen, d polypeptide; CD1d molecule; CD1d; differentiation antigen CD1-alpha-3; HMC class I antigen-like glycoprotein CD1D; MGC34622; R3; R3G1; T-cell surface glycoprotein CD1d; thymocyte antigen CD1D


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