Human CD8+ T Cell Enrichment Column, Small, Pack of 4

Name: Human CD8+ T Cell Enrichment Column, Small, Pack of 4
Brand: R&D Systems
SKU: HCD8C-1000
Rating: 5 (1 reviews)

R&D Systems | Catalog # HCD8C-1000

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Citations (3)

Product Documents

Discontinued Product

HCD8C-1000 has been discontinued. An alternative/replacement product is available: MAGH112. View all CD8 products.

Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas
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Key Product Details

Species

Human

Formulation, Preparation, and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: CD8

CD8, also known as Ly-2 or Leu-2, is a heterodimeric glycoprotein (alpha and beta subunits) that functions in conjunction with the T cell receptor in the recognition of MHC class I/peptide complexes. CD8 alpha is expressed on double positive (CD4+8+) thymocytes and mature CD8+ cytolytic T cells, intraepithelial lymphocytes, some gamma-delta T cells, subsets of thymic and splenic dendritic cells, and peritoneal mast cells. It can form disulfide linked homodimers or heterodimers with CD8 beta. Thymic CD8+ DC express primarily alpha-beta heterodimers, while splenic CD8+ DC primarily express alpha-alpha homodimers. CD8 alpha+ DC can present viral antigenic peptides in complex with MHC I and prime CTL responses.